EEG was performed in 25 children with lymphoblastic tumors before and after the first chemotherapy course by BFM schedule to assess functional state of the central nervous system during chemotherapeutic treatment. Levels of N-acetylneuraminic acid, medium weight molecules, malonic dialdehyde, vitamins A and E, vanyllylmandelic acid were measured in 8 cases. Unlike healthy children the patients with lymphoblastic tumors presented EEG signs of central nervous system injury as changes in hypothalamuspituitary system due to marked endogeneous intoxication and decreased antioxidant potential. These changes increased after the first chemotherapy course and manifested themselves as enhanced -activity in frontocentral cerebral cortex and decreased 2-activity. The increased electrophysiological and biochemical parameters after chemotherapy suggested further deterioration of toxic injury of the brain.
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