Purpose of the study: to assess expression of particular and integral indicators of the systemic inflammatory reaction in patients with end-stage renal disease (ESRD) who receive replacement treatment by haemodialysis. Material and methods: 42 patients with ESRD caused by chronic glomerulonephritis (n=22), chronic pyelonephritis (n=12) and diabetic nephropathy (n=8) were studied. All patients received replacement treatment by programmed haemodialysis for 12 hours per week. Control group 68 healthy persons (18-84 years). Levels of CRP, IL-6, IL-8, IL-10, TNF- in blood plasma were measured before and after haemodialysis by immunochemiluminescent method (Immulite, «SIEMENS», USA). Results: In patients with ESRD an acute phase response and hypercytokinemia (most of all due to TNF- and IL-8) the rate of which reduced after haemodialysis were detected. Integral indices of cytokinemia (reactivity coefficient and level of reactivity RC and RL) are the most informative characteristics of systemic inflammatory reaction. Conclusion: The phenomenon of systemic inflammatory reaction plays a significant role in the pathogenesis of ESRD; the rate of the systemic inflammation reaction can be measured using the integrated indices of cytokinemia.
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