Состояние Свободнорадикальных Процессов В Эотроцтах Больных Сарком Мягкийх Тканей

The aim of this research was to study oxidative stress in red blood cells of the soft tissue sarcoma (STS) patients who underwent neoadjuvant chemotherapy (NACT). NACT method was combined with topical and systemic administration of cytotoxic drugs using autologous blood components for breeding drugs. The patients in main group were treated with NACT. The control group included STS patients who received surgical treatment alone. Content of malondialdehyde (MDA), activities of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase and glutathione-S-transferase were examined. There were significant increase of the MDA concentration, decreased SOD and CAT activities and compensatory enhancement of the glutathione-dependent enzymes activities in control group. These changes indicated that oxidative stress increased in the early postoperative period. After the NACT we observed a reliable normalization of the most studied parameters to the level of healthy donors. A 4-year follow-up of patients, who treated with NACT, showed that local recurrence and metastases of STS appeared in 5 out of 21 cases. The patients, who had not been treated with NACT, local recurrence and metastases of STS were showed in 12 out of 21 cases. In our opinion, reduction in the level of oxidative stress is one of the mechanisms responsible for the effectiveness of the proposed method.