Эндотелиопротективные, Кардиопротективные И Коронаролитические Эффекты Производных 3-Оксипиридина

Studying of endothelioprotective, cardioprotective and coronary activity of 3-oksipiridin derivatives, the drugs "Mexidol" and "Mexicor" was made in the laboratories of cardiofarmacology scientific research institute of Ecological medicine in experiments on rats and dogs. The received results have allowed to determine the expressed correction of endothelial dysfunction in application of the drugs "Mexidol" and "Mexicor" in a dose of 30 mg/kg. The application of "Mexicor" has allowed to achieve authentically the most expressive reducing of endothelial dysfunction quotient in comparison with the drug "Mexidol". Studying of coronary activity and influence on a frame of a phase coronary blood stream has determined, that the drugs influenced greatly on coronary activity in doses 0.25, 0.5 and 1 mg intracoronary.