The paper presents the study of 286 patients with spontaneous pneumotoraks. It was revealed that the patients with sings of CTD after similar methods of surgical treatment had more relapses and intermittent course of spontaneous pneumotoraks. We developed the models to predict the relapse rate of spontaneous pneumatoraks for the closest 12 month. Connective tissue dysplasia, surgical treatment with pleurodesis induction and history of smoking are the main predictors of model.