Препарат Гиалуроновой Кислоты "остенил" Для Лечения Гонартроза. Результаты Многоцентрового Рандомизированного Маскированного Годичного Исследования

Objective. To study efficacy and safety of the knee osteoarthritis treatment with hyaluronic acid preparation “Ostenil administered according to two dosing regimens 3 or 5 intra-articular injections performed with weekly intervals in a randomized controlled masked multicenter one year study. Material and methods. 140 pts with primary knee osteoarthritis of l-lll radiological stage were included in 7 centers of Russia. Group 1 pts received 5 Ostenil injections and group 2 pts 3 Ostenil injections with subsequent 2 masked injections of lidokain 2%. An independent investigator assessed efficacy with WOMAK skale before the treatment, in 1,5, 3,6, 9 and 12 months after treatment course completion. Results. 3 and 5 Ostenil intra-articular injections provided fast and significant improvement in 65-70% of pts with knee osteoarthritis. Effect of a single treatment course was lasted for at least one year in 45-50% of pts. Wfe did not reveal any differences in degree and duration of clinical improvement in pts received 3 and 5 injections. Our pts did not have serious adverse events connected with Ostenil administration. Conclusion. The study confirmed high efficacy of Ostenil in the treatment of knee osteoarthritis. Difference in improvement duration after 5 and 3 Ostenil injections was not revealed