The technology of solid-state modification of hyaluronic acid with sodium decahydroborate by deformation in Bridgman anvils has been developed. The deformation was carried out at a pressure of 1 GPa and a rotation angle of 500 degrees. The structure of obtained complexes has been studied. According to the Raman and infrared spectroscopy data, hyaluronic acid and polyborates are capable of forming a network of cyclic polychelate complexes with hyaluronic acid as polydentate ligands. The distribution of hyaluronic acid-based boron compound in organs and tissues in mice with melanoma B-16 has been studied after single intratumor administration. The maximum boron content in tumor was observed 15 min after drug administration, but decreased two times already in 1 h and more than 5 times in 3 h upon administration. The optimum time for BNCT session is 30 min after compound administration, when boron concentration in tumor is greater than 30 μg/g and exceeds that in the surrounding tissues. During this time, the tumor/muscle and tumor/blood concentration ratios were 3 and 5, respectively. The first stage of investigation shows that the proposed compound is non-toxic and has good prospects for use in BNCT.
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