ИНДИВИДУАЛЬНАЯ УСТОЙЧИВОСТЬ СТЕРЕОТИПОВ ИММУННОГО РЕАГИРОВАНИЯ И СОВРЕМЕННЫЕ ВОЗМОЖНОСТИ ИХ ДИАГНОСТИКИ ПРИ ТРАНСПЛАНТАЦИИ ОРГАНОВ (ИММУНО-ФИЗИОЛОГИЧЕСКИЙ АНАЛИЗ ПРОБЛЕМЫ)

The authors prove variants of immune reacting of an human organism in organ transplantation by existence of individual speci fi c programs of reacting on alloantigens which, using natural activatory and inhibitory mecha- nisms, form various degree of stability of two physiological stereotypes of “behavior of immune system” – ef- fectoric and tolerogenic. For identi fi cation of an individual predominant stereotype of recipient immune reacting on a graft and for forecasting changes of an immunological homeostasis in a human organism, authors suggest to use indexes of reactance of immune system – conservatism and plasticity which can be taped by selection of the conforming biomarkers. Now the system of markers characterizing in fl ammatory reactions (infections/ in fl ammation) for recognition organ rejection and related complications, is widely used. For forecasting of an individual dominant stereotype of reacting in immunologically quiet post-transplant follow-up authors suggest to study a system of informative cellular markers of adaptive immunity and to use them for a formation of complex informative diagnostic immuno-cellular modules.