Противоопухолевые Стероиды. 2. Синтез И Биологическая Активность Производных 11Α-Гидроксиэстра-1,3,5(10)-триенов С Бис-(2-хлорэтил)аминосодержащим Заместителем В Положении 11

Analogs of 11β-hydroxyestrone and 17α-ethynylestradiol with a cytotoxic bis(2-chloroethyl)amine-containing substituent were synthesized in two principal stages from the corresponding 11-hydroxysteroids. The introduction of this bulky fragment negatively influences the estrogenic and antitumor activities of the synthesized compounds.