89 women at the age of 45-65 years are examined within the bounds of routine inspection. Examination was carried out by the method of dual-energy x-ray absorptiometry in three points of skeleton (the lumbar part of backbone L1-L4, the proximal part of femur and distal part of forearm) by means of device QDR-4500 Elite of firm Hologic, USA. The marker of bone resorbtion (B-CrossLaps), the marker of bone formation (osteocalcin) and parathyroid hormone in blood serum of each woman were measured on the Elecsys 1010 and 2010 automated analyzer (Roche). The most expressed disorders of bone density in women of pre-and postmenopausal ages were accompanied by increase of levels B-CrossLaps, osteocalcin and parathyroid hormone in blood serum. B-CrossLaps is the most sensitive biochemical marker of decrease in bone density; this marker precedes increase of osteocalcin level and occurrence of densimetric signs of osteoporosis. On the basis of biochemical markers of bone turnover (B-CrossLaps and osteocalcin) and estimation of clinical-anamnestic risk factors, as well as being based on results of densitometry, the algorithm of early diagnostics of osteoporosis in the women of preand postmenopausal ages is developed.
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