Роль Оксида Азота В Регуляции Функции Перитонеальных Макрофагов У Крыс При Экспериментальном Нарушении Маточноплацентарного Кровообращения

Еxam of the activity of peritoneal macrophages, NO-dependent state and mechanisms of free radical processes in normal pregnancy and in the background of the experimental disturbance of the utero-placental circulation (DUPC) was done with using of white rats. With the introduction of L-NAME and DUPC in serum observed similar changes in the form of lower levels of total nitrate and nitrite, increasing free radical processes. Activity of peritoneal macrophages varies in the opposite way L-NAME significantly increases her, and DUPC decreases. When combined action of increased production of nitric oxide formation and nitrotirozine that under these conditions plays a protective role by providing adaptation impaired feto-placental blood flow to the needs of the fetus, the activity of macrophages corresponds to the intact rats.