Эффективность И Переносимость Антидепрессанта Из Группы Селективных Ингибиторов Обратного Захвата Серотонина — Пароксетина (адепресс) При Психовегетативном Синдроме В Рамках Тревожно-Депрессивных Расстройств

The objective of the investigation was to study the clinical efficacy, tolerability, and side effects of adepress in patients with mild and moderate anxiety-depressive disorders and psychoautonomic syndrome. The investigation included 30 outpatients, of whom 29 completed it. Monotherapy with adepress (paroxetine) was used in a dose of 10—20 mg/day for 8 weeks. Adverse reactions were observed in one-third of the patients within the first 2 weeks of therapy. Their intensity was not more than 3 visual analog scale scores. They required neither dose adjustment nor drug discontinuation and ceased spontaneously. After 8 weeks, the positive effect of the therapy was noted in all the patients. Adepress was found to show a high clinical efficacy and antidepressant, anxiolytic, and autonomic stabilizing activities. Adepress also normalized the sleep-wake cycle and diminished tension headache.