Оценка Перспективности Бинарных Каталитических Систем С Использованием Фталоцианинов И Аскорбиновой Кислоты Для Внутриплеврального Лечения Опухолевых Плевритов

In work the efficacy and tolerance of the binary catalytic systems with teraftal, oxycobalamin or ephyther as the catalyzators with ascorbic acid as the reducer by the intrapleural administration to mice with i.p. transplanted tumors is described. It was shown through efficacy of malignant pleurisy treatment, pleurodesis inducing and «acute» toxicity that the most perspective for clinical investigation are Oc+AA and Tph+AA. Tph+AA with molar parity of components as 1:100 demonstrates the best therapeutically data with high pleu-rodesis inducing, terapeutical index TI>1,5. Eph+AA with the used dosage do not demonstrate enough efficacy.