Cleft of lip and palate the most common of the congenital anomalies in Krasnodar region general Russian Count. Dynamic occur of analysis have frequently characterization, from 85 to 160 incidence per 100 000 newborns. From year 2001 have tendention to decrease. There is a tendency about close relation ship between bad ecology and frequently increasing of congenital anomalies Cleft of lip and palate of Krasnodar region