МОРФОФУНКЦИОНАЛЬНЫЕ ОСНОВЫ СОЗДАНИЯ ИСКУССТВЕННОЙ КОЖИ (ДЕРМАЛЬНЫХ ЭКВИВАЛЕНТОВ)

The review of literature data and own results of the authors on skin structure, and skin structural components epidermis, derma and hypoderm are given. The special attention for derma intercellular matrix and role of fibroblasts in its shaping was paid. The methods of isolation and cultivation of fibroblasts and collagen isolation from connective tissue and development prospects of this biotechnology direction were described. The creation of artificial derma and tissue equivalents and its application in clinic praxis to treat the skin damages under the action of chemical and physical factors were considered.