The article presents the author's own data on the determination of predictors of phenotypes of recurrent wheezingin children of early and preschool age, taking into account the instability of the phenotype after the expiration of timeand transformation into bronchial asthma (BA). The study included 83 children with the diagnosis of recurrent bronchitis(RB) at the age of 1 to 6 years. Based on the follow-up study which lasted for a six-year period, the children understudy were divided into 2 groups, taking into account the phenotypic characteristics. The first group included 39 (46,9 %) children with a favorable outcome of the disease, the second one – 44 (53,1 %) children diagnosed withbronchial asthma (BA) over the past period. When assessing risk factors for recurrent wheezing, it was revealed thatfood sensitization (p = 0,021), drug allergy (p = 0,021), eosinophilia (p = 0,034), increased IL-1β (p = 0,003), IL-4(p = 0,034), IL-6 (p = 0,009), IL-8 (p = 0,008) significantly affect the formation of the persistent wheezing phenotype.For the transient phenotype, the most significant predictors were comorbidities of the upper respiratory tract:rhinosinusitis (p = 0,008), adenoiditis (p = 0,008).The discovered predictors make it possible to identify the phenotypes of recurrent wheezing in children of earlyand preschool age, which will allow personalizing therapy and predicting the outcome of the disease.
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