СИНТЕЗ И ИССЛЕДОВАНИЕ БИОЛОГИЧЕСКОЙ АКТИВНОСТИ СУЛЬФАМИНОВЫХ ПРОИЗВОДНЫХ ПОЛИСАХАРИДОВ

New water-soluble starch derivatives, pectin, and Na-CMC containing sulfamic groups were obtained through reacting sulfamic acid with dialdehyde polysaccharide derivatives. The structure and composition of the obtained compounds was studied by IR spectroscopy, elemental (nitrogen, sulfur), and x-ray diffraction analysis.Sulfamic starch derivatives, pectin, and Na-CMC with different content of sulfamic groups were obtained by varying the concentration of sulfamic acid against dialdehyde polysaccharide derivatives. The optimal ratio which was found is equal to –СНО : NH2SO3H = 1,0 : 2,5.The interaction speed of sulfamic acid with dialdehyde starch derivatives, pectin, and Na-CMC was studied.Study results of the antibacterial and antifungal effect of sulfamic starch derivatives' sodium salts, pectin, and Na-CMC. Biological activity of the obtained compounds was studied at different concentrations such as 10, 25, 50 mg/ml disk diffusion method against Gram-positive and Gram-negative bacteria and fungi. It was found that synthesized compounds do not exhibit antifungal activity against Candida albicans. Nevertheless, they have antibacterial activity against Staphylococcus aureus, Staphylococcus epidermidis, Escherichia coli, Proteus vulgaris, Streptococcus faecalis, Streptococcus pyogenes, and Streptococcus faecalis at a concentration of 50 mg / ml.The dependence of antibacterial action of the sodium salt of sulfamic starch derivatives, pectin, and Na-CMC from concentration is shown.Direct dependence of the antibacterial activity of drugs was established through the quantitative content of sulfamic groups in polysaccharides. Study presents the results on acute toxicity of sulfamic polysaccharide derivatives. Based on the study results they can be attributed to class V-practically nontoxic substances.