Распределение Света По Глубине Опухолевого Очага И Эффективность Использования Терапевтического Излучения При Фотодинамической Терапии

The article is devoted to the theoretical estimation and analysis of relationship between optical absorption of photosen-sitizer in biological tissue under treatment and the dose of light required to efficiently affect the deepest layers of tumor during PDT. It is shown that high that the therapeutic irradiation duting PDT may be efficiency used in a spectral range of maximum transparency if biological tissue. On the other hand, it is shown that while increase of sensitizers absorption in tumor, e.g. by increase of its concentration, does enhance the efficiency of use of light up to some level, further increase of it might decrease the efficiency due to shadowing of deeper layers of the tumor by highly sensitizer upper layers.