Дозозависимые Противовоспалительные, Эндотелиопротективные И Кардиопротективные Эффекты Симвастатина В Эксперименте

The research of anti-inflammatory, endothelioprotective and cardioprotective activity of 3-hydroxy-3-methylglutaryl-CoA reductase simvastatine in L-NAME-induced nitric oxide deficiency in experiment was carried out. Results of research proved the presence of simvastatin's expressive anti-inflammatory, endothelioprotective and cardioprotective effects. The most expressive correction of endothelial dysfunction is observed in use of simvastatin in a dose 8,6 mg/kg. Cardiac load-carrying tests also revealed significant cardioprotective activity in use of simvastatin in a dose 8,6 mg/kg.