The local immunity system in lungs is permanently exposed to injurious action of a number of chemical, physical and biological factors. Among other things, these are mineral microparticles. This paper gives consideration to assessment of effects produced by the Vanginskiy and Kulikovskiy zeolite deposits on the local immunity in lungs. The authors used lowenergy laser radiation as a factor very likely to induce lipid peroxidation and reduce functional activity of alveolar macrophages and lymphocytes. The studies allow to conclude that unlike the Kulikovskiy deposit zeolites appeared to intensify free radical reactions and suppress the local immunity system, the Vanginskiy deposit zeolites exhibited immunoprotective and antioxidative properties.