A Comprehensive Review of Binary Ti-Cu Alloys for Biomedical Applications: Biocompatibility, Osseointegration, Antibacterial, and Biocorrosion Properties

The increasing demand for antibacterial and biocompatible materials in biomedical applications prompts the development of titanium-copper (Ti-Cu) alloys as promising candidates. These alloys attract wide attention due to their potent antibacterial activity against various bacteria. This study thoroughly reviews the antibacterial properties, biocompatibility, and corrosion performance of Ti-Cu alloys in different circumstances. The effects of copper content, processing routes, surface treatments, and other parameters on antibacterial efficacy, cytocompatibility, osseointegration, and corrosion resistance are analyzed. The investigation spans multiple length scales, examining factors from bulk alloy composition to microstructural features like intermetallic phases and their morphology, distribution, and surface characteristics including topography and wettability. Ultimately, the ongoing challenges associated with Ti-Cu biomedical alloys are critically evaluated, mapping out strategic research directions to fully harness their multifunctional capabilities.