A Family of Ampa-Selective Glutamate Receptors

K Keinänen, W Wisden,B Sommer,P Werner,A Herb,T A Verdoorn,B Sakmann,P H Seeburg

Science（1990）SCI 1区

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Laboratory of Molecular Neuroendocrinology

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Four cloned cDNAs encoding 900-amino acid putative glutamate receptors with approximately 70 percent sequence identity were isolated from a rat brain cDNA library. In situ hybridization revealed differential expression patterns of the cognate mRNAs throughout the brain. Functional expression of the cDNAs in cultured mammalian cells generated receptors displaying α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA)-selective binding pharmacology (AMPA = quisqualate > glutamate > kainate) as well as cation channels gated by glutamate, AMPA, and kainate and blocked by 6,7-dinitroquinoxaline-2,3-dione (CNQX).

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Glutamate Receptors,NMDA Receptors

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