The multi-objective feature selection problem typically involves two key objectives: minimizing the number of selected features and maximizing classification performance. However, most multi-objective evolutionary algorithms (MOEAs) face challenges in high-dimensional datasets, including low search efficiency and potential loss of search space. To address these challenges, this paper proposes a hybrid algorithm based on fast dimensionality reduction and multi-objective differential evolution with redundant and preference processing (termed DR-RPMODE). In DR-RPMODE, the DR phase uses the freezing and activation operators to remove many irrelevant and redundant features in the high-dimensional datasets, thereby achieving fast dimensionality reduction. Subsequently, the RPMODE algorithm continues the search on the reduced datasets, improving the traditional differential evolutionary framework from two aspects: duplicated and redundant solutions are filtered by redundant handling, and a preference handling method that pays more attention to classification performance is designed for different preference objectives of decision-makers. In the experiment, DR-RPMODE is compared with seven feature selection algorithms on 16 classification datasets. The results indicate that DR-RPMODE outperforms the comparison algorithms on most datasets, demonstrating that it not only achieves outstanding optimization performance but also obtains good classification and scalability results.