Multiple Origin AS (MOAS) outsourcing mitigation is a defense countermeasure against prefix hijacking, during which the mitigation AS attracts and redirects the hijacked traffic to the legitimate origin AS by announcing the hijacked prefix. In order to enhance the effectiveness of mitigation, this paper proposes a node selection method for the mitigation AS. Specially, it takes multiple dimensions of AS topology into considerations: the hierarchical type, the Internet eXchange Point (IXP) access and the neighbor relationships of the AS. Experimental results show that the proposed method can achieve better mitigation effect against prefix hijacking compared other methods.