015 ACCELERATION OF OSTEOARTHRITIS PROGRESSION BY INDUCED EXPRESSION OF DISCOIDIN DOMAIN RECEPTOR 2 IN MATURE ARTICULAR CARTILAGE OF MOUSE KNEE JOINTS

Presentations / Osteoarthritis and Cartilage 18, Supplement 2 (2010) S9-S44 S15 ferences were found in the percentages of the immune cell populations studied between these tissues, luminex analyses of fat-conditioned media revealed significantly higher concentrations of IL-6, TNFα, adipsin and adiponectin from IFP than Sc adipose tissue.Similar differences were found in adipocyte-conditioned media from these two adipose tissues.Moreover, a positive correlation between TNFα release from fat-conditioned medium and body mass index was found in IFP (r = 0.338, p = 0.046).Conclusions: We show profound differences in inflammatory factors secreted from IFP compared to Sc adipose tissue.Moreover, our data indicate an influence of BMI on the inflammatory mediators released by IPF.In summary, these data suggest that IFP is qualitatively different from Sc adipose tissue and IFP-derived soluble mediators could contribute to pathophysiological processes in the OA knee joint.