Assessing the Impact of Boldine on the Gastrocnemius Using Multiomics Profiling at 7 and 28 Days Post-Complete Spinal Cord Injury in Young Male Mice.

This is the first study to describe the multiome of skeletal muscle paralyzed by a spinal cord injury (SCI) in mice across the acute and subacute timeframe after injury. We show large-scale changes in the metabolome and transcriptome at 7 days post-injury compared with 28 days. Furthermore, we show that the alkaloid boldine was able to prevent SCI-induced changes in muscle glucose and free amino acid levels at 7 days, but not 28 days, after SCI.