Assessment of Sodium Dodecanoyloxybenzenesulfonate As a Novel Biocide in Sprague–Dawley Rats Following 13-Week Repeated Dermal Administration

Sodium hypochlorite (NaOCl) is a biocidal substance widely used in household bleaching products and industrial applications. However, repeated, or long-term dermal exposure poses risks to human health. To address these concerns, the present study evaluated the potential dermal toxicity of sodium dodecanoyloxybenzenesulfonate (LOBS), which was developed as an alternative to NaOCl as a disinfectant and bleaching agent. This 13-week repeated dermal toxicity study was conducted in compliance with Organisation for Economic Co-operation and Development (OECD) Test Guideline 411. LOBS was administered dermally for 13 weeks and no treatment-related mortality or systemic toxicity was observed. No toxicologically meaningful changes were detected in body weight, food consumption, hematological or clinical chemistry parameters. Furthermore, no alterations were observed in organ weights, or gross and histopathological examinations of major organs. Local reactions observed at the injection site and on the skin were mild and reversible, and were not considered adverse effects related to the test substance. Based on these findings, the no observed adverse effect level for LOBS was determined to be 1000 mg/kg/day for both males and female SD rats. The results indicate that LOBS has an acceptable toxicological profile following repeated dermal exposure. Additionally, this study provides safety data supporting its use as a disinfectant and bleaching agent.