The acquisition of animal genome-editing individuals is a complex and time-consuming process. The use of genome-editing technology alone can only obtain edited cells. In order to efficiently obtain animals with edited genomes, it is necessary to combine it with other related technologies. This chapter systematically introduces some technologies related to animal genome editing, such as microinjection technology, somatic cell nuclear transfer technology, RNA interference, and other technologies, and systematically expounds on the operation process, precautions, and existing problems of related technologies in combination with examples in experimental work. We hope to provide constructive suggestions for the subsequent improvement of relevant technologies.