Association of Serum Vitamin D Level with Diabetic Polyneuropathy in Rural Population of Central India

To evaluate association of serum Vitamin D level and development of polyneuropathy. This was a case -control study and the study was conducted on an outpatient basis. Fifty-five subjects were recruited from the Medicine OPD of UPUMS Saifai. All subjects had type-2 diabetes (male and female, 40-60 years old). The Michigan Neuropathy Screening Instrument (15-point questionnaire) was used to identify patients with neuropathy (score > 7/15). 20 patients did not have neuropathy and were designated the control group. 35 patients did have neuropathy (“study group”) and these patients underwent a detailed quantitative neuropathy evaluation by a neurologist using the 46-point Michigan Diabetic Neuropathy Scale (MDNS) and nerve conduction studies. We measured the serum 25-hydroxyvitamin D concentrations with liquid chromatography-tandem mass spectrometry (LC/MS) chromatography in all patients. These values were compared between the control and study group, and were correlated with the detailed neuropathy score in the study group. Patients with diabetic polyneuropathy had a lower mean serum 25- hydroxyvitamin D level (16. 41 ng/ml with the SD of: 2.026) in comparison to the controls (38.76 ng/ml with the SD of 5.483).