Baclofen and Frankincense Containing Bigel, Hydrogel and Oleogel: A Novel Drug Delivery System to Relief Pain

Pain is an unpleasant sensory experience and a leading cause of medical consultations. Researchers are constantly seeking effective pain relief with minimal side effects. In fact, effective topical formulations with rapid antinociceptive effects are critical for pain relief. The aim of this study was to prepare an effective topical gel with antinociceptive effects. Three different gel types (hydrogel, oleogel, and bigel) were prepared to deliver baclofen and frankincense oil topically for pain relief. The physicochemical properties of the gels were analyzed, and their in-vivo effectiveness was assessed using capsaicin as a positive control. Hydrogel was prepared using Carbomer 940 and Pluronic F-127 as gelling agents, while oleogel was prepared using beeswax and Pluronic F-127 as gelling agents. Bigel was prepared using a mixture of these ingredients at different concentrations. The concentrations of baclofen and frankincense oil were 2