Objectives: This study was conducted to verify the efficacy of Bencao Shengji ointment (BSO) in treating third-degree burn wounds in mice. Methods: In this study, a mouse model of third-degree burn wounds was established, and the mice were randomly divided into three groups. In Group A, a gel containing recombinant human epidermal growth factor was applied externally. In Group B, BSO was applied externally, and in Group C, Bencao Nursing Solution (BNS) was applied externally. The efficacy of traditional Chinese herbal medicine preparations was verified by observing and comparing burn wound healing, inflammatory reactions and scar formation in the skin of mice in the three groups from Day 4 to Day 60. Results: The wound healing in Groups B and C was better than that in Group A from Day 4 to Day 14. Compared with those in Group B and Group C, the degree of wound necrosis and extent of inflammatory reactions in Group A were greater. From Day 15 to Day 45, the scars that formed after healing in Group A were more obvious, and the scars that formed in Group B were the smallest. On the 60th day, the mice in Group B had the shallowest burn scars on their skin, whereas the mice in both Group A and Group C exhibited moderate to severe scar formation. Conclusions: BSO can better promote the healing of third-degree burn wounds and reduce the formation of scars.
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