Benzo[alpha]pyrene Metabolism, Activation and Carcinogenesis: Role and Regulation of Mixed-Function Oxidases and Related Enzymes.

Benzo[alpha]pyrene metabolism, activation and carcinogenesis: role and regulation of mixed-function oxidases and related enzymes.H V GelboinH V GelboinPublished Online:01 Oct 1980https://doi.org/10.1152/physrev.1980.60.4.1107MoreSectionsPDF (9 MB)Download PDF ToolsExport citationAdd to favoritesGet permissionsTrack citations ShareShare onFacebookTwitterLinkedInEmail Previous Back to Top Next FiguresReferencesRelatedInformationCited ByLung genotoxicity of benzo(a)pyrene in vivo involves reactivation of LINE-1 retrotransposon and early reprogramming of oncogenic regulatory networksA. A. I. Hassanin, M. Tavera-Garcia, B. Moorthy, G. D. Zhou, and K. S. 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ONE, Vol. 13, No. 5Chemoresistance to Cancer Treatment: Benzo-α-Pyrene as Friend or Foe?17 April 2018 | Molecules, Vol. 23, No. 4PARP1 protects from benzo[a]pyrene diol epoxide-induced replication stress and mutagenicity1 December 2017 | Archives of Toxicology, Vol. 92, No. 3The Aldo-Keto Reductase Superfamily ☆Nucleoside Modification Using Buchwald-Hartwig Amination ReactionsControllable self-assembled plasmonic vesicle-based three-dimensional SERS platform for picomolar detection of hydrophobic contaminants1 January 2018 | Nanoscale, Vol. 10, No. 27A highly sensitive and selective two-photon fluorescent probe for real-time sensing of cytochrome P450 1A1 in living systems1 January 2018 | Materials Chemistry Frontiers, Vol. 27Altered gene expression profiles in the lungs of benzo[ a ]pyrene-exposed mice in the presence of lipopolysaccharide-induced pulmonary inflammationToxicology and Applied Pharmacology, Vol. 336Computational Simulations of DNA Polymerases: Detailed Insights on Structure/Function/Mechanism from Native Proteins to Cancer Variants6 September 2017 | Chemical Research in Toxicology, Vol. 30, No. 11Molecular characterization of ABC transporters in marine ciliate, Euplotes crassus : Identification and response to cadmium and benzo[ a ]pyreneMarine Pollution Bulletin, Vol. 124, No. 2Inactivation possibility of pyrene by C 20 fullerene via cycloaddition reactions: A theoretical studyComputational and Theoretical Chemistry, Vol. 1112Oral microemulsion of phytoconstituent found in licorice as chemopreventive against benzo( a )pyrene induced forestomach tumors in experimental mice modelJournal of Drug Delivery Science and Technology, Vol. 39Flow cytometry detection of planktonic cells with polycyclic aromatic hydrocarbons sorbed to cell surfacesMarine Pollution Bulletin, Vol. 118, No. 1-2Transcriptome analysis of Eisenia fetida chronically exposed to benzo(a)pyreneEnvironmental Technology & Innovation, Vol. 7Deep Learning to Predict the Formation of Quinone Species in Drug Metabolism2 February 2017 | Chemical Research in Toxicology, Vol. 30, No. 2The aryl hydrocarbon receptor repressor – More than a simple feedback inhibitor of AhR signaling: Clues for its role in inflammation and cancerCurrent Opinion in Toxicology, Vol. 2Carcinogenesis of the Oral Cavity: Environmental Causes and Potential Prevention by Black Raspberry2 December 2016 | Chemical Research in Toxicology, Vol. 30, No. 1Naringenin ameliorates inflammation and cell proliferation in benzo(a)pyrene induced pulmonary carcinogenesis by modulating CYP1A1, NFκB and PCNA expressionInternational Immunopharmacology, Vol. 30Effects of Benzo[ a ]pyrene Exposure on Human Hepatocellular Carcinoma Cell Angiogenesis, Metastasis, and NF- κ B SignalingEnvironmental Health Perspectives, Vol. 123, No. 3Human Aldo-Keto Reductases and the Metabolic Activation of Polycyclic Aromatic Hydrocarbons16 October 2014 | Chemical Research in Toxicology, Vol. 27, No. 11Surface reactions on the cytoplasmatic membranes—Mathematical modeling of reaction and diffusion systems in a cellJournal of Computational and Applied Mathematics, Vol. 262Interception of Benzo[ a ]pyrene-7,8-dione by UDP Glucuronosyltransferases (UGTs) in Human Lung Cells3 October 2013 | Chemical Research in Toxicology, Vol. 26, No. 10Genotoxicity-Related Chemistry of Human Metabolites of Benzo[ ghi ]perylene (B[ ghi ]P) Investigated using Electro-Optical Arrays and DNA/Microsome Biocolloid Reactors with LC-MS/MS8 August 2013 | Chemical Research in Toxicology, Vol. 26, No. 8p53 Mutagenesis by Benzo[ a ]pyrene Derived Radical Cations9 August 2012 | Chemical Research in Toxicology, Vol. 25, No. 10Chemical Reaction of Soybean Flavonoids with DNA: A Computational Study Using the Implicit Solvent Model25 January 2012 | International Journal of Molecular Sciences, Vol. 13, No. 2Aldo-Keto Reductases Protect Lung Adenocarcinoma Cells from the Acute Toxicity of B[ a ]P-7,8- trans -Dihydrodiol16 November 2011 | Chemical Research in Toxicology, Vol. 25, No. 1Harmful and Beneficial Effects of Organic Monosulfides, Disulfides, and Polysulfides in Animals and Humans28 October 2011 | Chemical Research in Toxicology, Vol. 25, No. 1CYP1A1, CYP2E1, and GSTM1 Gene Polymorphisms and Susceptibility to Colorectal and Gastric Cancer Among LebaneseGenetic Testing and Molecular Biomarkers, Vol. 15, No. 6Metabolic Diversity in Bacterial Degradation of Aromatic CompoundsOMICS: A Journal of Integrative Biology, Vol. 11, No. 3Renal vascular and tubulointerstitial inflammation and proliferation in Cyp1a1-Ren2 transgenic rats with inducible ANG II-dependent malignant hypertensionMiguel L. Graciano, Cynthia R. Mouton, Matthew E. Patterson, Dale M. Seth, John J. Mullins, and Kenneth D. Mitchell1 June 2007 | American Journal of Physiology-Renal Physiology, Vol. 292, No. 6Cyclooxygenase-2 inhibition normalizes arterial blood pressure in CYP1A1-REN2 transgenic rats with inducible ANG II-dependent malignant hypertensionAllison L. Opay, Cynthia R. Mouton, John J. Mullins, and Kenneth D. Mitchell1 September 2006 | American Journal of Physiology-Renal Physiology, Vol. 291, No. 3Genetic Clamping of Renin Gene Expression Induces Hypertension and Elevation of Intrarenal Ang II Levels of Graded Severity in Cyp1a1-Ren2 Transgenic Rats22 July 2016 | Journal of the Renin-Angiotensin-Aldosterone System, Vol. 7, No. 2Enhanced tubuloglomerular feedback in Cyp1a1-Ren2 transgenic rats with inducible ANG II-dependent malignant hypertensionKenneth D. Mitchell, and John J. Mullins1 December 2005 | American Journal of Physiology-Renal Physiology, Vol. 289, No. 6Interactive effects of superoxide anion and nitric oxide on blood pressure and renal hemodynamics in transgenic rats with inducible malignant hypertensionMatthew E. Patterson, Cynthia R. Mouton, John J. Mullins, and Kenneth D. Mitchell1 October 2005 | American Journal of Physiology-Renal Physiology, Vol. 289, No. 4Salt-sensitive hypertension develops after transient induction of ANG II-dependent hypertension in Cyp1a1-Ren2 transgenic ratsLaura L. Howard, Matthew E. Patterson, John J. Mullins, and Kenneth D. Mitchell1 April 2005 | American Journal of Physiology-Renal Physiology, Vol. 288, No. 4Polymorphisms in the DNA repair gene XPD and susceptibility to esophageal squamous cell carcinomaCancer Genetics and Cytogenetics, Vol. 154, No. 1Screening for genotoxicity using the DRAG assay: investigation of halogenated environmental contaminantsMutation Research/Genetic Toxicology and Environmental Mutagenesis, Vol. 563, No. 1The use of mini-organ cultures of human upper aerodigestive tract epithelia in ecogenotoxicologyMutation Research/Genetic Toxicology and Environmental Mutagenesis, Vol. 561, No. 1-2Differential c-myc expression profiles in normal human bronchial epithelial cells following treatment with benzo[a]pyrene, benzo[a]pyrene-4,5 epoxide, and benzo[a]pyrene-7,8-9,10 diol epoxide1 January 2004 | Molecular Carcinogenesis, Vol. 40, No. 2Identification of cytochrome P450 isoforms involved in 1-hydroxylation of pyreneEnvironmental Research, Vol. 94, No. 3Effects of Schistosoma haematobium infection on drug-metabolizing enzymes in human bladder cancer tissuesCancer Letters, Vol. 205, No. 1Aldo-Keto Reductases and Formation of Polycyclic Aromatic Hydrocarbon o-QuinonesRegulation of Antioxidant Response Element–Dependent Induction of Detoxifying Enzyme SynthesisPOLYCYCLIC AROMATIC HYDROCARBON O -QUINONES MUTATE p 53 IN HUMAN LUNG ADENOCARCINOMA (A549) CELLSPolycyclic Aromatic Compounds, Vol. 24, No. 4-5Genetic susceptibility to dietary carcinogensEvaluation of impact of PAH on a tropical fish, Oreochromis mossambicus using multiple biomarkersChemosphere, Vol. 53, No. 8Bone marrow cytotoxicity of benzo[a]pyrene is dependent on CYP1B1 but is diminished by Ah receptor-mediated induction of CYP1A1 in liverToxicology and Applied Pharmacology, Vol. 193, No. 1Fas A670G polymorphism, apoptotic capacity in lymphocyte cultures, and risk of lung cancerLung Cancer, Vol. 42, No. 1Dose-response studies on the induction of liver cytochromes P4501A1 and 1B1 by polycyclic aromatic hydrocarbons in arylhydrocarbon-responsive C57BL/6J mice22 September 2008 | Xenobiotica, Vol. 33, No. 9From genotype to phenotype: correlating XRCC1 polymorphisms with mutagen sensitivityDNA Repair, Vol. 2, No. 8Single amino acid mutations, but not common polymorphisms, decrease the activity of CYP1B1 against (-)benzo[a]pyrene-7R-trans-7,8-dihydrodiol5 June 2003 | Carcinogenesis, Vol. 24, No. 7Coffee diterpenes prevent benzo[a]pyrene genotoxicity in rat and human culture systemsBiochemical and Biophysical Research Communications, Vol. 306, No. 2Genomic profiles and predictive biological networks in oxidant-induced atherogenesisC. D. Johnson, Y. Balagurunathan, K. P. Lu, M. Tadesse, M. H. Falahatpisheh, R. J. Carroll, E. R. Dougherty, C. A. Afshari, and K. S. Ramos13 May 2003 | Physiological Genomics, Vol. 13, No. 3Food MutagensThe Journal of Nutrition, Vol. 133, No. 3Exceptional activity of murine glutathione transferase A1-1 against (7R,8S)-dihydroxy-(9S,10R)-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene-induced DNA damage in stably transfected cells29 January 2003 | Molecular Carcinogenesis, Vol. 36, No. 2Tissue-specific induction of cytochromes P450 1A1 and 1B1 by polycyclic aromatic hydrocarbons and polychlorinated biphenyls in engineered C57BL/6J mice of arylhydrocarbon receptor geneToxicology and Applied Pharmacology, Vol. 187, No. 1Polycyclic aromatic hydrocarbon-inducible DNA adducts: Evidence by32P-postlabeling and use of knockout mice for Ah receptor-independent mechanisms of metabolic activationin vivo26 November 2002 | International Journal of Cancer, Vol. 103, No. 1Method for determining monohydroxybenzo[ a ]pyrene isomers using column-switching high-performance liquid chromatographyAnalytical Biochemistry, Vol. 312, No. 1Analysis of DNA and protein adducts of benzo[a]pyrene in human tissues using structure-specific methodsMutation Research/Reviews in Mutation Research, Vol. 543, No. 1Genetic polymorphism in myeloperoxidase but not GSTM1 is associated with risk of lung squamous cell carcinoma in a Chinese population22 October 2002 | International Journal of Cancer, Vol. 102, No. 3Polymorphisms of the DNA repair gene XPD and risk of lung cancer in a Chinese populationLung Cancer, Vol. 38, No. 2ENVIRONMENTAL CARCINOGENIC POLYCYCLIC AROMATIC HYDROCARBONS: PHOTOCHEMISTRY AND PHOTOTOXICITYJournal of Environmental Science and Health, Part C, Vol. 20, No. 2Metabolism of pyrene by two clam species, Mya arenaria and Protothaca stamineaChemosphere, Vol. 49, No. 3DETECTION OF DNA ADDUCTS IN DEVELOPING CD4 + CD8 + THYMOCYTES AND SPLENOCYTES FOLLOWING IN UTERO EXPOSURE TO BENZO[ a ]PYRENE9 September 2002 | Immunopharmacology and Immunotoxicology, Vol. 24, No. 3Modulation of Cytochrome P4501-mediated Bioactivation of Benzo[a]pyrene by Volatile Allyl Sulfides in Human Hepatoma Cells22 May 2014 | Bioscience, Biotechnology, and Biochemistry, Vol. 65, No. 10Maternal Exposure to Benzo[A]Pyrene Alters Development of T Lymphocytes in Offspring27 September 2008 | Immunopharmacology and Immunotoxicology, Vol. 21, No. 2Polycyclic aromatic hydrocarbons in placenta, maternal blood, umbilical cord blood and milk of Indian women2 July 2016 | Human & Experimental Toxicology, Vol. 14, No. 6Depression of hepatic cytochrome P450 monooxygenases after chronic environmental tobacco smoke exposure of young ferretsToxicology Letters, Vol. 76, No. 3Human peripheral blood lymphocytes as a cell model to evaluate the genotoxic effect of coal tar treatment.Environmental Health Perspectives, Vol. 102, No. suppl 9Predominance of glucuronidation over sulfation in metabolism of 1-hydroxybenzo[a]pyrene by isolated rat hepatocytesToxicology Letters, Vol. 74, No. 1Dioxin-receptor ligands in urban air and vehicle exhaust.Environmental Health Perspectives, Vol. 102, No. suppl 4Inhibition of estrogen-induced progesterone receptor in MCF-7 human breast cancer cells by aryl hydrocarbon (Ah) receptor agonistsMolecular and Cellular Endocrinology, Vol. 104, No. 1Regio- and stereo-selective metabolism of phenanthrene by twelve cDNA-expressed human, rodent, and rabbit cytochromes P-450Cancer Letters, Vol. 83, No. 1-2Effects of isothiocyanate alkyl chain-length on hamster liver cytochrome P-450 activityCancer Letters, Vol. 82, No. 2Bioactivation of benzo(a)pyrene-7,8-dihydrodiol catalyzed by lipoxygenase purified from human term placenta and conceptal tissuesReproductive Toxicology, Vol. 8, No. 4Modulative Effects of Metabolic Effectors on Benzo(A)Pyrene-Induced Cytotoxicity and Mutagenicity in Mammalian Cells1 May 1994 | Toxicology and Industrial Health, Vol. 10, No. 3Modulatory effect of piperine on benzo[a]pyrene cytotoxicity and DNA adduct formation in V-79 lung fibroblast cellsFood and Chemical Toxicology, Vol. 32, No. 4Different enzyme kinetics during the glutathione conjugation of the four stereoisomers of the fjord-region diolepoxides of benzo[c]phenanthrene by the μ-class rat liver glutathione S-transferase HTP IIBiochemical Pharmacology, Vol. 47, No. 3Daily and circadian rhythms in the activity of mixed function oxidases system in rats of different age22 September 2008 | Biological Rhythm Research, Vol. 25, No. 1Possible Mechanisms of Alteration in the Capacities of Carcinogen Metabolizing Enzymes during Schistosomiasis and Their Role in Bladder Cancer Induction25 June 2016 | Journal of International Medical Research, Vol. 21, No. 6Dihydrodiol dehydrogenase and its role in polycyclic aromatic hydrocarbon metabolismChemico-Biological Interactions, Vol. 89, No. 1Mutagenicity of chrysene, its methyl and benzo derivatives, and their interactions with cytochromes P-450 and the Ah-receptor; relevance to their carcinogenic potencyToxicology, Vol. 81, No. 1Pituitary as a target organ for toxic effects of P4501A1 inducing chemicalsMolecular and Cellular Endocrinology, Vol. 91, No. 1-2Immunohistochemical detection of pulmonary cytochrome P450IA and metabolic activities associated with P450IA1 and P450IA2 isozymes in lung cancer patients.Environmental Health Perspectives, Vol. 98Mechanism of antimutagenicity of wheat sprout extractsMutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, Vol. 269, No. 2Metabolism of benzo[a]pyrene by murine splenic cell typesToxicology and Applied Pharmacology, Vol. 116, No. 2Evaluation of murine splenic cell type metabolism of benzo[a]pyrene and functionality in vitro following repeated in vivo exposure to benzo[a]pyreneToxicology and Applied Pharmacology, Vol. 116, No. 2Polycyclic aromatic hydrocarbon (PAH) ortho-quinone conjugate chemistry: Kinetics of thiol addition to PAH ortho-quinones and structures of thioether adducts of naphthalene-1,2-dioneChemico-Biological Interactions, Vol. 84, No. 2Altered regulation of Cyp 1a-1 gene expression during cultivation of mouse hepatocytes in primary cultureBiochemical Pharmacology, Vol. 44, No. 1DNA damage induced by cigarette smoke condensate in vitro as assayed by 32P-postlabeling. Comparison with cigarette smoke-associated DNA adduct profiles in vivoMutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, Vol. 268, No. 1Generation of 7,8-dihydroxy-9,10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene by murine splenic macrophagesToxicology and Applied Pharmacology, Vol. 115, No. 1Monoclonal antibodies to rat liver microsomal cytochrome b5Biochemical Pharmacology, Vol. 43, No. 10Effects of synthetic and naturally occurring flavonoids on metabolic activation of benzo[a]pyrene in hamster embryo cell culturesChemico-Biological Interactions, Vol. 82, No. 2Interaction of mineral fibres with lung cytochrome P-450 system: Impairment of drug metabolizing enzyme activitiesChemosphere, Vol. 24, No. 8Effect of cadmium on some enzyme activities in first-trimester human placentaeToxicology Letters, Vol. 60, No. 2Cigarette Smoke Inhibits Cytosolic but not Microsomal Epoxide Hydrolase of Human Lung2 July 2016 | Human & Experimental Toxicology, Vol. 11, No. 2Comparative metabolism of 7H-dibenzo[c,g]carbazole and dibenz[a,j]acridine by mouse and rat liver microsomesChemico-Biological Interactions, Vol. 81, No. 1-2Microsomal activation of benzo[a]pyrene to mutagens by Alligator mississippiensis in vitro: induction by 3-methylcholanthreneMarine Environmental Research, Vol. 34, No. 1-4Xenobiotic metabolizing enzyme activity in the liver and kidney of the brown bullhead (Ictalurus nebulosus)Marine Environmental Research, Vol. 34, No. 1-4The approach to understanding aromatic hydrocarbon carcinogenesis. The central role of radical cations in metabolic activationPharmacology & Therapeutics, Vol. 55, No. 2Carcinogen-mediated oxidant formation and oxidative DNA damagePharmacology & Therapeutics, Vol. 53, No. 1Multistage carcinogenesis in mouse skinPharmacology & Therapeutics, Vol. 54, No. 1Comparative tumor-initiating ability of 7H-dibenzo(c,g)carbazole and dibenz(a,j)acridine in mouse skinToxicology, Vol. 71, No. 3Effects of synthetic and naturally occurring flavonoids on benzo[a]pyrene metabolism by hepatic microsomes prepared from rats treated with cytochrome P-450 inducersCancer Letters, Vol. 60, No. 1Biotransformation of scoparone used to monitor changes in cytochrome P450 activities in primary hepatocyte cultures derived from rats, hamsters and monkeysBiochemical Pharmacology, Vol. 41, No. 8cDNA-expressed human cytochrome P450s: a new age of molecular toxicology and human risk assessmentMutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, Vol. 247, No. 12,3,7,8-tetrachlorodibenzo-P-dioxin induces cytochrome P450IA1 enzyme activity by activating transcription of the corresponding geneAdvances in Enzyme Regulation, Vol. 31The effect of toluene on rat lung benzo[a]pyrene metabolism and microsomal membrane lipidsToxicology, Vol. 68, No. 1Mapping of phenytoin-inducible cytochrome P450 immunoreactivity in the mouse central nervous systemNeuroscience, Vol. 42, No. 1Metabolism of benzo[a]pyrene and persistence of DNA adducts in the brown bullhead (Ictalurus nebulosus)Comparative Biochemistry and Physiology Part C: Comparative Pharmacology, Vol. 100, No. 1-2Cytochrome P-450 monooxygenase systems in aquatic species: carcinogen metabolism and biomarkers for carcinogen and pollutant exposure.Environmental Health Perspectives, Vol. 90Stable Expression of Mouse Cyplal and Human CYP1A2 cDNAs Transfected into Mouse Hepatoma Cells Lacking Detectable P450 Enzyme ActivityDNA and Cell Biology, Vol. 9, No. 6Inhibition of liver microsome-mediated mutagenesis, metabolism and DNA-binding of benzo[a]pyrene and benzo[a]pyrene 7,8-dihydrodiol in the rat following glucose administrationCancer Letters, Vol. 50, No. 2Reduced benzo-a-pyrene activation potential in lymphocytes from chronic alcoholicsAlcohol, Vol. 7, No. 2Conjugation of benzo[a]pyrene metabolites by freshwater green alga Selenastrum capricornutumChemico-Biological Interactions, Vol. 74, No. 1-2Metabolism of benzo[a]pyrene and (−)-trans-benzo[a]pyrene-7,8-dihydrodiol by freshly isolated hepatocytes of brown bullheadsChemico-Biological Interactions, Vol. 74, No. 1-2Effect of chrysotile asbestos on cytochrome P-450-dependent monooxygenase and glutathione-S-transferase activities in rat lungChemico-Biological Interactions, Vol. 75, No. 3Polycyclic aromatic hydrocarbons affect the calcium ionophore induced activation of rabbit plateletChemosphere, Vol. 21, No. 1-2Localization, distribution, and induction of xenobiotic-metabolizing enzymes and aryl hydrocarbon hydroxylase activity within lungPharmacology & Therapeutics, Vol. 47, No. 3The role of glutathione S-transferases in the hepatic metabolism of benzo[a]pyrene in white suckers (Catostomus commersoni) from polluted and reference sites in the great lakesComparative Biochemistry and Physiology Part C: Comparative Pharmacology, Vol. 95, No. 1Monoclonal antibodies to rat liver cytochrome P-450 2c/RLM5 that regiospecifically inhibit steroid metabolismBiochemical Pharmacology, Vol. 38, No. 18Antimutagenic activity of green tea polyphenolsMutation Research/Genetic Toxicology, Vol. 223, No. 3The control of cytochrome P-450 gene expression by dioxinTrends in Pharmacological Sciences, Vol. 10, No. 7DNA damage and repair in female C57BL/10 mice of different ages injected with the carcinogen benzo[a]pyrene-trans-7,8-diolMutation Research/DNAging, Vol. 219, No. 4Transient Superinducibility of Cytochrome P450c (CYP1A1) mRNA and TranscriptionDNA, Vol. 8, No. 5Microsomal and cytosolic epoxide hydrolase and glutathione S-transferase activities in the gill, liver, and kidney of the rainbow trout, Salmo gairdneriBiochemical Pharmacology, Vol. 38, No. 6Metabolic action of polycyclic aromatic hydrocarbons to mutagens in the Ames test by various animal species including manMutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, Vol. 211, No. 1The Mechanisms of Action of Reproductive Toxicants25 June 2016 | Toxicologic Pathology, Vol. 17, No. 2Influence of the carcinogenic pollutant benzo[a]pyrene on plant development: Fern gametophytesChemico-Biological Interactions, Vol. 72, No. 3Benzo[a]pyrene-DNA-adducts and monooxygenase activities in mice treated with benzo[a]pyrene, cigarette smoke or cigarette smoke condensateChemico-Biological Interactions, Vol. 70, No. 1-2Glutathione transferase catalyzed conjugation of benzo[a]pyrene 7,8-diol 9,10-epoxide with glutathione in human skinChemico-Biological Interactions, Vol. 70, No. 1-2Benzo[a]pyrene metabolism in isolated perfused rainbow trout gillsMarine Environmental Research, Vol. 28, No. 1-4Xenobiotic metabolism by isolated pulmonary cellsPharmacology & Therapeutics, Vol. 41, No. 1-2The relative importance of Ah versus H-2 genetype on Trichinella resistance following exposure to 3-methylcholanthreneInternational Journal of Immunopharmacology, Vol. 11, No. 2In vivo and in vitro metabolism of benzo(a)pyrene by the larva of the newt, Peurodeles waltlComparative Biochemistry and Physiology Part C: Comparative Pharmacology, Vol. 93, No. 2Differential expression of glutathione transferases by native and cultured human lymphocytesBiochemical Pharmacology, Vol. 37, No. 23Carcinogenicity of benzo[a]pyrene in rainbow trout resulting from embryo microinjectionAquatic Toxicology, Vol. 13, No. 4The ontogeny of coho salmon (Oncorhynchus kisutch) behavior following embryonic exposure to benzo[a]pyreneAquatic Toxicology, Vol. 13, No. 4Immunohistochemical detection of CCl4-induced, mitosis-related DNA synthesis in livers of trout and ratAquatic Toxicology, Vol. 13, No. 2Effect of nutritional imbalances on cytochrome P-450 isozymes in rat liverBiochemical Pharmacology, Vol. 37, No. 17Qualitative and quantitative differences in the induction and inhibition of hepatica benzo[a]pyrene metabolism in the rat and hamsterBiochemical Pharmacology, Vol. 37, No. 8Metabolism of benzo(A)pyrene by a dioxygenase enzyme system of the freshwater green alga selenastrum capricornutumBiochemical and Biophysical Research Communications, Vol. 152, No. 2Benzo[ a ]pyrene: Kinetics of In Vitro Bioactivation in Relation to Inhibition of Viral Interferon InductionJournal of Interferon Research, Vol. 8, No. 2Metabolic activation of environmental carcinogens and mutagens by human liver microsomesBiochemical Pharmacology, Vol. 37, No. 3Metabolism of mutagenic polycyclic aromatic hydrocarbons by photosynthetic algal speciesMutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, Vol. 197, No. 2Stereoselectivity of cytochrome P-450 isozymes and epoxide hydrolase in the metabolism of polycyclic aromatic hydrocarbonsBiochemical Pharmacology, Vol. 37, No. 1Interactions of hepatic cytochromes P-450 with steroid hormonesBiochemical Pharmacology, Vol. 37, No. 1Benzo[a]pyrene metabolism and induction of enzymealtered foci in regenerating rat liverChemico-Biological Interactions, Vol. 67, No. 3-4Microsomal metabolism of piceneChemico-Biological Interactions, Vol. 66, No. 3-4An isolated perfused model for the study of colonic metabolism and transportJournal of Surgical Research, Vol. 44, No. 13-Methylcholanthrene does induce mixed function oxidase activity in hepatopancreas of spiny crab Maja crispataComparative Biochemistry and Physiology Part C: Comparative Pharmacology, Vol. 90, No. 2A role for dietary lipids and antioxidants in the activation of carcinogensFree Radical Biology and Medicine, Vol. 5, No. 2A comparison of the binding and distribution of benzo[a]pyrene in human and rat serumToxicology, Vol. 47, No. 3Comparative carcinogenic potencies of 7H-dibenzo[c,g]carbazole, dibenz[a,j]acridine and benzo[a]pyrene in mouse skinCancer Letters, Vol. 37, No. 3Ontogeny of the chicken cytochrome P-450 enzyme systemBiochemical Pharmacology, Vol. 36, No. 18Pulmonary aryl hydrocarbon hydroxylase activity of mice, rats and guinea pigs following long term exposure to mainstream and sidestream cigarette smokeToxicology, Vol. 45, No. 2Cytochrome P-450-mediated activation of pro-carcinogens and promutagens to DNA-damaging products by measuring expression of umu gene in Salmonella typhimurium TA1535/pSK1002Biochemical Pharmacology, Vol. 36, No. 12Modulation of the cytotoxicity and mutagenicity of benzo[a]pyrene and benzo[a]pyrene 7,8-diol by glutathione and glutathione S-transferases in mammalian cells (CHO/HGPRT assay)Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, Vol. 178, No. 2Nutrition in the Prevention of Neoplastic Disease in the ElderlyClinics in Geriatric Medicine, Vol. 3, No. 2Biotransformation of caffeine by microsomes from human liverBiochemical Pharmacology, Vol. 36, No. 8Immunohistochemical localization of cytochrome P-450 in rat brainNeuroscience, Vol. 20, No. 3Product inhibition of benzo[a]pyrene metabolism in uninduced rat liver microsomes: Effect of diol epoxide formationChemico-Biological Interactions, Vol. 61, No. 2Increased stability of (±)-7 β ,8 α -dihydroxy-9 α ,10 α -epoxy-7,8,9,10-tetrahydrobenzo[ a ]pyrene through interaction with subcellular fractions of rat liverChemico-Biological Interactions, Vol. 61, No. 1Vitamin K1 amplification of benzo(a)pyrene metabolism in chick embryosInternational Journal of Biochemistry, Vol. 19, No. 5Effects of superoxide generated in vitro on glucuronidation of benzo[a]pyrene metabolites by mouse liver microsomesInternational Journal of Biochemistry, Vol. 19, No. 6Biochemical changes taking place in mitogen-treated lymphocytesTemporal changes in AHH and SOD activities in feral spot from the Elizabeth River, a polluted sub-estuaryMarine Environmental Research, Vol. 23, No. 2Metabolic characterization of human liver microsomal cytochromes P-450 involved in the oxidation of debrisoquine, bufuralol and the carcinogen 2-acetylaminofluorenePha