Biological greenish nanosynthesis of silver nanoparticle using plant leaf essential oil compound farnesol and their antifungal activity against human pathogenic fungi

Plant oil compounds could be an alternative to traditional biological methods for the production of metallic nanomaterials in a clean, nontoxic and ecologically sound manner. In the present study, we aimed to develop a rapid ecofriendly method for the synthesis of silver nanoparticles with plant oil compound farnesol. The bioactive constitutes of these plant oil compound farnesol seems to play a role in the production of metal nanoparticles. Moreover, rapid biosynthesis of silver nanoparticles occurred only at alkaline media. The production of nanoparticles by this method is extremely fast, ecofriendly and stable for several weeks with no additional surfactants. The silver nanoparticles were synthesized by five different methods and the completion of the reaction was monitored with UV-visible spectrophotometer. The XRD result showed the powdery nature of nanoparticles, SEM-EDX analysis was employed for the characterization of synthesized silver nanoparticles was small dot shaped structure. The particle size was found to be 58 nm, possessing spherical shape as confirmed from TEM analysis and the FTIR result predicted the presence of chemical compounds in this oil compound The antifungal activity results showed that synthesized silver nanoparticle from the plant oil compound farnesol was moderately active against clinically isolated human fungal pathogens, Aspergillus niger, Aspergillus flavus, Candida albicans, Candida tropicalis and Candida kefyr. WORLD JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES SJIF Impact Factor 5.210 Volume 4, Issue 09, 1706-1717 Research Article ISSN 2278 – 4357 Article Received on 11 July 2015, Revised on 06 Aug 2015, Accepted on 31 Aug 2015