Brine Shrimp: a Convenient General Bioassay for Active Plant Constituents.

BN MEYER,NR FERRIGNI,JE PUTNAM,LB JACOBSEN,DE NICHOLS,JL MCLAUGHLIN

Planta medica（1982）SCI 3区SCI 2区

PURDUE UNIV

被引用7823|浏览9

摘要

A method, utilizing brine shrimp (Artemia salina Leach), is proposed as a simple bioassay for natural product research. The procedure determines LC (50) values in microg/ml of active compounds and extracts in the brine medium. Activities of a broad range of known active compounds are manifested as toxicity to the shrimp. Screening results with seed extracts of 41 species of Euphorbiaceae were compared with 9KB and 9PS cytotoxicities. The method is rapid, reliable, inexpensive, and convenient as an in-house general bioassay tool.

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关键词

Biological Activities