To foster sustained improvements in clinician well-being, health care organizations must prioritize systemic changes. Overcoming barriers to transformation within large health systems requires training distributed leaders- both formally designated and informally recognized-in the principles of organizational well-being, process improvement, and change management. Effective training initiatives should extend beyond assessing knowledge to including ongoing evaluations of impact after program completion. This article reviews the current evidence supporting well-being-centered leadership development and presents Scholars of Wellness as a case study. Scholars of Wellness cultivates champions of wellbeing across our organization and has demonstrated sustained improvements through individual projects and by developing well-being-centered leaders to improve our organization's health.