Tumour-initiating cells (TICs) share functional properties, such as clonogenicity and capability for multilineage differentiation, with normal stem cells. However, Howard Fine and colleagues hypothesized that there might be differences in their differentiation potential and found that epigenetic silencing of bone morphogenetic protein (BMP) receptor 1B (BMPR1B) blocks differentiation in a subset of glioblastoma TICs and contributes to their tumorigenicity.
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