Cellular Senescence, Target of Interest to Optimize the Success of Pancreatic Islet Transplantation

Pancreatic islet transplantation is a therapeutic option that has great potential for treating Type 1 Diabetes (T1D). However, the number of people with T1D who can benefit from it is limited by the need for 2 or 3 pancreas to treat a patient. In a recent publication, we reviewed the limitations and challenges of successful islet transplantation [1]. Although this information was insightful, it would have been interesting to discuss senescence, a process that can affect the physiology and function of pancreatic islets [2].