We asked young scientists these questions: Have you ever encountered a particularly stark dif erence between an old and new position in your education or career? What was the dif erence between the positions, and what advice would you give to someone making a similar transition? Here, respondents share the challenges they faced when they took on new responsibilities and roles, changed fi elds, or moved to new places. To others in similar situations, they advise: Be confi dent, prepared, and patient; communicate; and always ask