Chitosan-based Nano-Encapsulation Enhances the Anti-Diabetic Efficacy of Eremina Desertorum Extract by Ameliorating Hyperglycemia, Oxidative Stress, and Inflammation in Diabetic Rats

This study developed a novel Eremina desertorum snail extract (Ere extract) loaded-chitosan nanoparticles (Ere-CS NPs) to enhance the anti-diabetic efficacy of Eremina desertorum snail extract. The nanoparticles, synthesized via ionic gelation, were spherical ( 80 nm) and exhibited storage stability when lyophilized, with consistent physicochemical properties upon reconstitution over a 90-day period, high encapsulation efficiency (73.56