•Diagnosis of CCE-CI is challenging due to nonspecific neurological symptoms.•Brain DWI revealed multiple small ischemic lesions among patients with CCE-CI.•CCE-CI was associated with atherosclerotic plaques in the ascending aorta and arch.•CCE-CI was also associated with lower eGFR and higher blood eosinophil count.•CCE-CI is associated with aortic aneurysm morbidity.