Circus Movement in Rabbit Atrial Muscle As a Mechanism of Tachycardia. III. the "leading Circle" Concept: a New Model of Circus Movement in Cardiac Tissue Without the Involvement of an Anatomical Obstacle.

HomeCirculation ResearchVol. 41, No. 1Circus movement in rabbit atrial muscle as a mechanism of tachycardia. III. The "leading circle" concept: a new model of circus movement in cardiac tissue without the involvement of an anatomical obstacle. Free AccessAbstractPDF/EPUBAboutView PDFSections ToolsAdd to favoritesDownload citationsTrack citationsPermissions ShareShare onFacebookTwitterLinked InMendeleyReddit Jump toFree AccessAbstractPDF/EPUBCircus movement in rabbit atrial muscle as a mechanism of tachycardia. III. The "leading circle" concept: a new model of circus movement in cardiac tissue without the involvement of an anatomical obstacle. M A Allessie, F I Bonke and F J Schopman M A AllessieM A Allessie Search for more papers by this author , F I BonkeF I Bonke Search for more papers by this author and F J SchopmanF J Schopman Search for more papers by this author Originally published1 Jul 1977https://doi.org/10.1161/01.RES.41.1.9Circulation Research. 1977;41:9–18 Previous Back to top Next FiguresReferencesRelatedDetailsCited By Ono K, Iwasaki Y, Akao M, Ikeda T, Ishii K, Inden Y, Kusano K, Kobayashi Y, Koretsune Y, Sasano T, Sumitomo N, Takahashi N, Niwano S, Hagiwara N, Hisatome I, Furukawa T, Honjo H, Maruyama T, Murakawa Y, Yasaka M, Watanabe E, Aiba T, Amino M, Itoh H, Ogawa H, Okumura Y, Aoki-Kamiya C, Kishihara J, Kodani E, Komatsu T, Sakamoto Y, Satomi K, Shiga T, Shinohara T, Suzuki A, Suzuki S, Sekiguchi Y, Nagase S, Hayami N, Harada M, Fujino T, Makiyama T, Maruyama M, Miake J, Muraji S, Murata H, Morita N, Yokoshiki H, Yoshioka K, Yodogawa K, Inoue H, Okumura K, Kimura T, Tsutsui H and Shimizu W (2022) JCS/JHRS 2020 Guideline on Pharmacotherapy of Cardiac Arrhythmias, Circulation Journal, 10.1253/circj.CJ-20-1212, Online publication date: 11-Mar-2022. Qu Z, Liu M, Olcese R, Karagueuzian H, Garfinkel A, Chen P and Weiss J (2022) R-on-T and the initiation of reentry revisited: Integrating old and new concepts, Heart Rhythm, 10.1016/j.hrthm.2022.03.1224, Online publication date: 1-Mar-2022. Yang B, Lowenthal J, Tomaselli G and Tung L (2022) Human iPSC models of cardiac electrophysiology and arrhythmia iPSCs - State of the Science, 10.1016/B978-0-323-85767-3.00006-2, (29-93), . de Groot N, Shah D, Boyle P, Anter E, Clifford G, Deisenhofer I, Deneke T, van Dessel P, Doessel O, Dilaveris P, Heinzel F, Kapa S, Lambiase P, Lumens J, Platonov P, Ngarmukos T, Martinez J, Sanchez A, Takahashi Y, Valdigem B, van der Veen A, Vernooy K, Casado-Arroyo R, De Potter T, Dinov B, Kosiuk J, Linz D, Neubeck L, Svennberg E, Kim Y, Wan E, Lopez-Cabanillas N, Locati E and Macfarlane P (2021) Critical appraisal of technologies to assess electrical activity during atrial fibrillation: a position paper from the European Heart Rhythm Association and European Society of Cardiology Working Group on eCardiology in collaboration with the Heart Rhythm Society, Asia Pacific Heart Rhythm Society, Latin American Heart Rhythm Society and Computing in Cardiology, EP Europace, 10.1093/europace/euab254, 24:2, (313-330), Online publication date: 2-Feb-2022. Herndon C, Astley H, Owerkowicz T and Fenton F (2021) Defibrillate You Later, Alligator: Q10 Scaling and Refractoriness Keeps Alligators from Fibrillation, Integrative Organismal Biology, 10.1093/iob/obaa047, 3:1, Online publication date: 27-Jan-2021. (2021) Mechanisms, Classification, and Clinical Aspects of Arrhythmias Clinical Electrocardiography, 10.1002/9781119536475.ch14, (297-320), Online publication date: 6-Dec-2021. Siles J, Salinet J, Pollnow S, Dossel O and Uzelac I (2021) Estimation of the Ablated Area size based on Local Conduction Velocity Simulations and animal experiments 2021 Computing in Cardiology (CinC), 10.23919/CinC53138.2021.9662765, 978-1-6654-7916-5, (1-4) Sun M, de Groot N and Hendriks R (2021) Cardiac tissue conductivity estimation using confirmatory factor analysis, Computers in Biology and Medicine, 10.1016/j.compbiomed.2021.104604, 135, (104604), Online publication date: 1-Aug-2021. Tomii N, Yamazaki M, Ashihara T, Nakazawa K, Shibata N, Honjo H and Sakuma I (2021) Spatial phase discontinuity at the center of moving cardiac spiral waves, Computers in Biology and Medicine, 10.1016/j.compbiomed.2021.104217, 130, (104217), Online publication date: 1-Mar-2021. Nitti A, Kiendl J, Gizzi A, Reali A and de Tullio M (2021) A curvilinear isogeometric framework for the electromechanical activation of thin muscular tissues, Computer Methods in Applied Mechanics and Engineering, 10.1016/j.cma.2021.113877, 382, (113877), Online publication date: 1-Aug-2021. Ioannidis P, Zografos T, Christoforatou E, Kouvelas K, Tsoumeleas A, Vassilopoulos C and Chen R (2021) The Electrophysiology of Atrial Fibrillation: From Basic Mechanisms to Catheter Ablation, Cardiology Research and Practice, 10.1155/2021/4109269, 2021, (1-14), Online publication date: 5-Jun-2021. Buist T, Zipes D and Elvan A (2020) Atrial fibrillation ablation strategies and technologies: past, present, and future, Clinical Research in Cardiology, 10.1007/s00392-020-01751-5, 110:6, (775-788), Online publication date: 1-Jun-2021. Sumners D, Cruz-White I and Ricca R (2021) Zero helicity of Seifert framed defects, Journal of Physics A: Mathematical and Theoretical, 10.1088/1751-8121/abf45c, 54:29, (295203), Online publication date: 23-Jul-2021. Bezzerides V and Pu W (2020) Two sides of the same coin: new insights into mechanisms of ventricular fibrillation, Cardiovascular Research, 10.1093/cvr/cvaa246, 117:4, (983-984), Online publication date: 21-Mar-2021. Cakulev I, Wit A and Waldo A (2021) The History of Mapping Cardiac Bioelectric Therapy, 10.1007/978-3-030-63355-4_3, (27-40), . Roney C, Wit A and Peters N (2020) Challenges Associated with Interpreting Mechanisms of AF, Arrhythmia & Electrophysiology Review, 10.15420/aer.2019.08, 8:4, (273-284), Online publication date: 11-Feb-2020. Tung R, Raiman M, Liao H, Zhan X, Chung F, Nagel R, Hu H, Jian J, Shatz D, Besser S, Aziz Z, Beaser A, Upadhyay G, Nayak H, Nishimura T, Xue Y and Wu S (2020) Simultaneous Endocardial and Epicardial Delineation of 3D Reentrant Ventricular Tachycardia, Journal of the American College of Cardiology, 10.1016/j.jacc.2019.12.044, 75:8, (884-897), Online publication date: 1-Mar-2020. Vernemmen I, De Clercq D, Decloedt A, Vera L, Van Steenkiste G and van Loon G (2019) Atrial premature depolarisations five days post electrical cardioversion are related to atrial fibrillation recurrence risk in horses, Equine Veterinary Journal, 10.1111/evj.13186, 52:3, (374-378), Online publication date: 1-May-2020. Pedro B, Fontes-Sousa A and Gelzer A (2020) Canine atrial fibrillation: Pathophysiology, epidemiology and classification, The Veterinary Journal, 10.1016/j.tvjl.2020.105548, 265, (105548), Online publication date: 1-Nov-2020. Burashnikov A and Antzelevitch C (2020) Mechanisms Underlying the Development of Cardiac Arrhythmias Management of Cardiac Arrhythmias, 10.1007/978-3-030-41967-7_2, (33-74), . Roberts J and Gollob M (2020) A Molecular Genetic Perspective on Atrial Fibrillation Clinical Cardiogenetics, 10.1007/978-3-030-45457-9_18, (287-305), . Aksu T, Guler T, Bozyel S and Yalin K (2020) Usage of a new mapping algorithm to detect possible critical substrate for continuity of atrial fibrillation: fractionation mapping in preliminary experience, Journal of Interventional Cardiac Electrophysiology, 10.1007/s10840-019-00693-x, 58:1, (29-34), Online publication date: 1-Jun-2020. Lakin R, Polidovitch N, Yang S, Guzman C, Gao X, Wauchop M, Burns J, Izaddoustdar F and Backx P (2019) Inhibition of soluble TNFα prevents adverse atrial remodeling and atrial arrhythmia susceptibility induced in mice by endurance exercise, Journal of Molecular and Cellular Cardiology, 10.1016/j.yjmcc.2019.01.012, 129, (165-173), Online publication date: 1-Apr-2019. Totz J (2019) Confined Scroll Rings Synchronization and Waves in Active Media, 10.1007/978-3-030-11057-4_2, (13-35), . Beaumont J (2019) Dynamics of Pivoting Electrical Waves in a Cardiac Tissue Model, Bulletin of Mathematical Biology, 10.1007/s11538-019-00623-y, 81:7, (2649-2690), Online publication date: 1-Jul-2019. Ciaccio E, Wan E, Saluja D, Acharya U, Peters N and Garan H (2019) Addressing challenges of quantitative methodologies and event interpretation in the study of atrial fibrillation, Computer Methods and Programs in Biomedicine, 10.1016/j.cmpb.2019.06.017, 178, (113-122), Online publication date: 1-Sep-2019. Shenasa M and Al-Ahmad A (2019) Historical Perspectives on Cardiac Mapping and Ablation, Cardiac Electrophysiology Clinics, 10.1016/j.ccep.2019.06.001, 11:3, (405-408), Online publication date: 1-Sep-2019. Walters T, Lee G and Kalman J (2019) Mechanisms of Persistent Atrial Fibrillation Cardiac Mapping, 10.1002/9781119152637.ch61, (780-797) Mena A and Bea J (2019) Multiscale Numerical Simulation of Heart Electrophysiology Advances in Biomechanics and Tissue Regeneration, 10.1016/B978-0-12-816390-0.00007-8, (115-138), . Thomas D, Christ T, Fabritz L, Goette A, Hammwöhner M, Heijman J, Kockskämper J, Linz D, Odening K, Schweizer P, Wakili R and Voigt N (2018) German Cardiac Society Working Group on Cellular Electrophysiology state-of-the-art paper: impact of molecular mechanisms on clinical arrhythmia management, Clinical Research in Cardiology, 10.1007/s00392-018-1377-1, 108:6, (577-599), Online publication date: 1-Jun-2019. Carstensen H, Hesselkilde E, Haugaard M, Flethøj M, Carlson J, Pehrson S, Jespersen T, Platonov P and Buhl R (2019) Effects of dofetilide and ranolazine on atrial fibrillatory rate in a horse model of acutely induced atrial fibrillation, Journal of Cardiovascular Electrophysiology, 10.1111/jce.13849, 30:4, (596-606), Online publication date: 1-Apr-2019. Zhu C, Hanna P, Rajendran P and Shivkumar K (2019) Neuromodulation for Ventricular Tachycardia and Atrial Fibrillation, JACC: Clinical Electrophysiology, 10.1016/j.jacep.2019.06.009, 5:8, (881-896), Online publication date: 1-Aug-2019. Fontaine G, Li G, Saguner A and Frank R (2019) Mechanisms of torsade de pointes tachycardia in patients with spontaneous high-degree atrioventricular block: A modern look at old data, Journal of Electrocardiology, 10.1016/j.jelectrocard.2019.05.007, 56, (55-63), Online publication date: 1-Sep-2019. Issa Z, Miller J and Zipes D (2019) Electrophysiological Mechanisms of Cardiac Arrhythmias Clinical Arrhythmology and Electrophysiology, 10.1016/B978-0-323-52356-1.00003-7, (51-80), . Williams S, O’Neill L, Roney C, Julia J, Metzner A, Reißmann B, Mukherjee R, Sim I, Whitaker J, Wright M, Niederer S, Sohns C and O’Neill M (2019) Left atrial effective conducting size predicts atrial fibrillation vulnerability in persistent but not paroxysmal atrial fibrillation, Journal of Cardiovascular Electrophysiology, 10.1111/jce.13990, 30:9, (1416-1427), Online publication date: 1-Sep-2019. Panfilov A (2019) Spiral Waves in the Heart Spirals and Vortices, 10.1007/978-3-030-05798-5_11, (209-215), . Nattel S and Algalorrondo V (2019) Clinical Relevance of Functional Models of Atrial Reentry and Fibrillation Cardiac Mapping, 10.1002/9781119152637.ch37, (473-481) Aras K, Boukens B, Ripplinger C, Gloschat C and Efimov I (2019) Optical Mapping of Successful and Failed Defibrillation Cardiac Mapping, 10.1002/9781119152637.ch35, (448-463) Ganesan P, Salmin A, Cherry E, Huang D, Pertsov A and Ghoraani B (2019) Iterative navigation of multipole diagnostic catheters to locate repeating‐pattern atrial fibrillation drivers, Journal of Cardiovascular Electrophysiology, 10.1111/jce.13872, 30:5, (758-768), Online publication date: 1-May-2019. Aras K, Faye N, Cathey B and Efimov I (2018) Critical Volume of Human Myocardium Necessary to Maintain Ventricular Fibrillation, Circulation: Arrhythmia and Electrophysiology, 11:11, Online publication date: 1-Nov-2018. Mann I, Sandler B, Linton N and Kanagaratnam P (2018) Drivers of Atrial Fibrillation: Theoretical Considerations and Practical Concerns, Arrhythmia & Electrophysiology Review, 10.15420/aer.2017.40.3, 7:1, (1), . Russo V, Papa A, Rago A, Ciardiello C, Marano M, Proietti R, Politano L and Nigro G (2018) Interatrial block to predict atrial fibrillation in myotonic dystrophy type 1, Neuromuscular Disorders, 10.1016/j.nmd.2018.01.010, 28:4, (327-333), Online publication date: 1-Apr-2018. Kawata H and Birgersdotter-Green U (2018) Ventricular Fibrillation and Defibrillation Encyclopedia of Cardiovascular Research and Medicine, 10.1016/B978-0-12-809657-4.99764-3, (674-682), . Houston C, Tzortzis K, Roney C, Saglietto A, Pitcher D, Cantwell C, Chowdhury R, Ng F, Peters N and Dupont E (2018) Characterisation of re-entrant circuit (or rotational activity) in vitro using the HL1-6 myocyte cell line, Journal of Molecular and Cellular Cardiology, 10.1016/j.yjmcc.2018.05.002, 119, (155-164), Online publication date: 1-Jun-2018. Guettler N, Nicol E, Schmitt J and Rajappan K (2018) Mechanisms of Atrial Fibrillation and Their Impact on Strategies for Catheter Ablation, European Journal of Arrhythmia & Electrophysiology, 10.17925/EJAE.2018.4.2.56, 4:2, (56), . Raiman M and Tung R (2018) Automated isochronal late activation mapping to identify deceleration zones: Rationale and methodology of a practical electroanatomic mapping approach for ventricular tachycardia ablation, Computers in Biology and Medicine, 10.1016/j.compbiomed.2018.07.012, 102, (336-340), Online publication date: 1-Nov-2018. Calkins H, Hindricks G, Cappato R, Kim Y, Saad E, Aguinaga L, Akar J, Badhwar V, Brugada J, Camm J, Chen P, Chen S, Chung M, Cosedis Nielsen J, Curtis A, Davies D, Day J, d’Avila A, (Natasja) de Groot N, Di Biase L, Duytschaever M, Edgerton J, Ellenbogen K, Ellinor P, Ernst S, Fenelon G, Gerstenfeld E, Haines D, Haissaguerre M, Helm R, Hylek E, Jackman W, Jalife J, Kalman J, Kautzner J, Kottkamp H, Kuck K, Kumagai K, Lee R, Lewalter T, Lindsay B, Macle L, Mansour M, Marchlinski F, Michaud G, Nakagawa H, Natale A, Nattel S, Okumura K, Packer D, Pokushalov E, Reynolds M, Sanders P, Scanavacca M, Schilling R, Tondo C, Tsao H, Verma A, Wilber D, Yamane T, Blomström-Lundqvist C, De Paola A, Kistler P, Lip G, Peters N, Pisani C, Raviele A, Saad E, Satomi K, Stiles M and Willems S (2017) 2017 HRS/EHRA/ECAS/APHRS/SOLAECE expert consensus statement on catheter and surgical ablation of atrial fibrillation, EP Europace, 10.1093/europace/eux274, 20:1, (e1-e160), Online publication date: 1-Jan-2018. Park H, Jeong D, Yu H, Pak H, Shim J, Kim J, Kim J, Lee J, Kim K, Roh S, Cho Y, Kim Y and Yoon N (2018) 2018 Korean Guidelines for Catheter Ablation of Atrial Fibrillation: Part I, International Journal of Arrhythmia, 10.18501/arrhythmia.2018.011, 19:3, (186-234) Birgersdotter-Green U (2018) OBSOLETE: Ventricular Fibrillation and Defibrillation Reference Module in Biomedical Sciences, 10.1016/B978-0-12-801238-3.99764-2, . Narayan S, Vishwanathan M, Kowalewski C, Baykaner T, Rodrigo M, Zaman J and Wang P (2017) The continuous challenge of AF ablation: From foci to rotational activity, Revista Portuguesa de Cardiologia, 10.1016/j.repc.2017.09.007, 36, (9-17), Online publication date: 1-Nov-2017. (2017) Electrophysiologic Mechanisms Clinical Arrhythmology, 10.1002/9781119212782.ch3, (53-82) GALLO C, BOCCHINO P, MAGNANO M, GAIDO L, ZEMA D, BATTAGLIA A, ANSELMINO M and GAITA F (2017) Autonomic Tone Activity Before the Onset of Atrial Fibrillation, Journal of Cardiovascular Electrophysiology, 10.1111/jce.13150, 28:3, (304-314), Online publication date: 1-Mar-2017. Enriquez A, Frankel D and Baranchuk A (2017) Pathophysiology of ventricular tachyarrhythmiasPathophysiologie ventrikulärer Tachyarrhythmien, Herzschrittmachertherapie + Elektrophysiologie, 10.1007/s00399-017-0512-4, 28:2, (149-156), Online publication date: 1-Jun-2017. Ng G (2017) Feasibility of selection of antiarrhythmic drug treatment on the basis of arrhythmogenic mechanism — Relevance of electrical restitution, wavebreak and rotors, Pharmacology & Therapeutics, 10.1016/j.pharmthera.2016.10.002, 176, (1-12), Online publication date: 1-Aug-2017. Blom N, Gorgels A, Hauer R, van Hemel N and Wilde A (2017) Ritmestoornissen Klinische elektrocardiografie, 10.1007/978-90-368-0330-4_5, (75-162), . Leybaert L, Lampe P, Dhein S, Kwak B, Ferdinandy P, Beyer E, Laird D, Naus C, Green C, Schulz R and Levy F (2017) Connexins in Cardiovascular and Neurovascular Health and Disease: Pharmacological Implications, Pharmacological Reviews, 10.1124/pr.115.012062, 69:4, (396-478), Online publication date: 1-Oct-2017. Narayan S, Rodrigo M, Kowalewski C, Shenasa F, Meckler G, Vishwanathan M, Baykaner T, Zaman J and Wang P (2017) Ablation of Focal Impulses and Rotational Sources: What Can Be Learned from Differing Procedural Outcomes?, Current Cardiovascular Risk Reports, 10.1007/s12170-017-0552-7, 11:9, Online publication date: 1-Sep-2017. Salinet J, Schlindwein F, Stafford P, Almeida T, Li X, Vanheusden F, Guillem M and Ng G (2017) Propagation of meandering rotors surrounded by areas of high dominant frequency in persistent atrial fibrillation, Heart Rhythm, 10.1016/j.hrthm.2017.04.031, 14:9, (1269-1278), Online publication date: 1-Sep-2017. Marcotte C and Grigoriev R (2017) Dynamical mechanism of atrial fibrillation: A topological approach, Chaos: An Interdisciplinary Journal of Nonlinear Science, 10.1063/1.5003259, 27:9, (093936), Online publication date: 1-Sep-2017. Robinson V and Nattel S (2017) Basic Electrophysiology Cardiac Arrhythmias, Pacing and Sudden Death, 10.1007/978-3-319-58000-5_1, (1-13), . Valli H, Ahmad S, Chadda K, Al-Hadithi A, Grace A, Jeevaratnam K and Huang C (2017) Age-dependent atrial arrhythmic phenotype secondary to mitochondrial dysfunction in Pgc-1β deficient murine hearts, Mechanisms of Ageing and Development, 10.1016/j.mad.2017.09.002, 167, (30-45), Online publication date: 1-Oct-2017. Rossi S, Buccarello A, Ershler P, Lux R, Callegari S, Corradi D, Carnevali L, Sgoifo A, Miragoli M, Musso E and Macchi E (2017) Effect of anisotropy on ventricular vulnerability to unidirectional block and reentry by single premature stimulation during normal sinus rhythm in rat heart, American Journal of Physiology-Heart and Circulatory Physiology, 10.1152/ajpheart.00366.2016, 312:3, (H584-H607), Online publication date: 1-Mar-2017. Calkins H, Hindricks G, Cappato R, Kim Y, Saad E, Aguinaga L, Akar J, Badhwar V, Brugada J, Camm J, Chen P, Chen S, Chung M, Nielsen J, Curtis A, Davies D, Day J, d’Avila A, deGroot N, Di Biase L, Duytschaever M, Edgerton J, Ellenbogen K, Ellinor P, Ernst S, Fenelon G, Gerstenfeld E, Haines D, Haissaguerre M, Helm R, Hylek E, Jackman W, Jalife J, Kalman J, Kautzner J, Kottkamp H, Kuck K, Kumagai K, Lee R, Lewalter T, Lindsay B, Macle L, Mansour M, Marchlinski F, Michaud G, Nakagawa H, Natale A, Nattel S, Okumura K, Packer D, Pokushalov E, Reynolds M, Sanders P, Scanavacca M, Schilling R, Tondo C, Tsao H, Verma A, Wilber D and Yamane T (2017) WITHDRAWN: 2017 HRS/EHRA/ECAS/APHRS/SOLAECE expert consensus statement on catheter and surgical ablation of atrial fibrillation, Journal of Arrhythmia, 10.1016/j.joa.2017.07.001, Online publication date: 1-Sep-2017. Nattel S, Xiong F and Aguilar M (2017) Demystifying rotors and their place in clinical translation of atrial fibrillation mechanisms, Nature Reviews Cardiology, 10.1038/nrcardio.2017.37, 14:9, (509-520), Online publication date: 1-Sep-2017. Osadchii O (2017) Role of abnormal repolarization in the mechanism of cardiac arrhythmia, Acta Physiologica, 10.1111/apha.12902, 220, (1-71), Online publication date: 1-Jul-2017. Calkins H, Hindricks G, Cappato R, Kim Y, Saad E, Aguinaga L, Akar J, Badhwar V, Brugada J, Camm J, Chen P, Chen S, Chung M, Nielsen J, Curtis A, Davies D, Day J, d’Avila A, de Groot N, Di Biase L, Duytschaever M, Edgerton J, Ellenbogen K, Ellinor P, Ernst S, Fenelon G, Gerstenfeld E, Haines D, Haissaguerre M, Helm R, Hylek E, Jackman W, Jalife J, Kalman J, Kautzner J, Kottkamp H, Kuck K, Kumagai K, Lee R, Lewalter T, Lindsay B, Macle L, Mansour M, Marchlinski F, Michaud G, Nakagawa H, Natale A, Nattel S, Okumura K, Packer D, Pokushalov E, Reynolds M, Sanders P, Scanavacca M, Schilling R, Tondo C, Tsao H, Verma A, Wilber D and Yamane T (2017) 2017 HRS/EHRA/ECAS/APHRS/SOLAECE expert consensus statement on catheter and surgical ablation of atrial fibrillation, Heart Rhythm, 10.1016/j.hrthm.2017.05.012, 14:10, (e275-e444), Online publication date: 1-Oct-2017. Vandersickel N, Bossu A, De Neve J, Dunnink A, Meijborg V, van der Heyden M, Beekman J, De Bakker J, Vos M and Panfilov A (2017) Short-Lasting Episodes of Torsade de Pointes in the Chronic Atrioventricular Block Dog Model Have a Focal Mechanism, While Longer-Lasting Episodes Are Maintained by Re-Entry, JACC: Clinical Electrophysiology, 10.1016/j.jacep.2017.06.016, 3:13, (1565-1576), Online publication date: 1-Dec-2017. Thomas D, Jex N and Thornley A (2017) Ventricular arrhythmias in acute coronary syndromes-mechanisms and management, Continuing Cardiology Education, 10.1002/cce2.51, 3:1, (22-29), Online publication date: 1-Mar-2017. Orini M, Nanda A, Yates M, Di Salvo C, Roberts N, Lambiase P and Taggart P (2017) Mechano-electrical feedback in the clinical setting: Current perspectives, Progress in Biophysics and Molecular Biology, 10.1016/j.pbiomolbio.2017.06.001, 130, (365-375), Online publication date: 1-Nov-2017. Narayan S, Vishwanathan M, Kowalewski C, Baykaner T, Rodrigo M, Zaman J and Wang P (2017) The continuous challenge of AF ablation: From foci to rotational activity, Revista Portuguesa de Cardiologia (English Edition), 10.1016/j.repce.2017.12.001, 36, (9-17), Online publication date: 1-Nov-2017. Quintanilla J, Pérez-Villacastín J, Pérez-Castellano N, Pandit S, Berenfeld O, Jalife J and Filgueiras-Rama D (2016) Mechanistic Approaches to Detect, Target, and Ablate the Drivers of Atrial Fibrillation, Circulation: Arrhythmia and Electrophysiology, 9:1, Online publication date: 1-Jan-2016. GROSSI S, GRASSI F, GALLEANI L, BIANCHI F, SIBONA MASI A and CONTE M (2016) Atrial Conduction Velocity Correlates with Frequency Content of Bipolar Signal, Pacing and Clinical Electrophysiology, 10.1111/pace.12884, 39:8, (814-821), Online publication date: 1-Aug-2016. Tinker A, Finlay M, Nobles M and Opel A (2016) The contribution of pathways initiated via the Gq\11 G-protein family to atrial fibrillation, Pharmacological Research, 10.1016/j.phrs.2015.11.008, 105, (54-61), Online publication date: 1-Mar-2016. Yamabe H, Kanazawa H, Ito M, Kaneko S and Ogawa H (2016) Prevalence and mechanism of rotor activation identified during atrial fibrillation by noncontact mapping: Lack of evidence for a role in the maintenance of atrial fibrillation, Heart Rhythm, 10.1016/j.hrthm.2016.07.030, 13:12, (2323-2330), Online publication date: 1-Dec-2016. PROIETTI R, ROUX J, VERMA A, ALTURKI A, BERNIER M and ESSEBAG V (2016) A Historical Perspective on the Role of Functional Lines of Block in the Re-entrant Circuit of Ventricular Tachycardia, Pacing and Clinical Electrophysiology, 10.1111/pace.12827, 39:5, (490-496), Online publication date: 1-May-2016. Berenfeld O and Jalife J (2016) Mechanisms of Atrial Fibrillation, Heart Failure Clinics, 10.1016/j.hfc.2015.08.014, 12:2, (167-178), Online publication date: 1-Apr-2016. Aguilar M and Nattel S (2016) The pioneering work of George Mines on cardiac arrhythmias: groundbreaking ideas that remain influential in contemporary cardiac electrophysiology, The Journal of Physiology, 10.1113/JP270506, 594:9, (2377-2386), Online publication date: 1-May-2016. Lip G, Fauchier L, Freedman S, Van Gelder I, Natale A, Gianni C, Nattel S, Potpara T, Rienstra M, Tse H and Lane D (2016) Atrial fibrillation, Nature Reviews Disease Primers, 10.1038/nrdp.2016.16, 2:1, Online publication date: 22-Dec-2016. Roberts J and Gollob M (2016) A Molecular Genetic Perspective on Atrial Fibrillation Clinical Cardiogenetics, 10.1007/978-3-319-44203-7_15, (227-245), . Laughner J, Shome S, Child N, Shuros A, Neuzil P, Gill J and Wright M (2016) Practical Considerations of Mapping Persistent Atrial Fibrillation With Whole-Chamber Basket Catheters, JACC: Clinical Electrophysiology, 10.1016/j.jacep.2015.09.017, 2:1, (55-65), Online publication date: 1-Feb-2016. Attuel G, Pont O, Xu B and Yahia H (2016) Sudden Cardiac Death and Turbulence The Foundations of Chaos Revisited: From Poincaré to Recent Advancements, 10.1007/978-3-319-29701-9_14, (235-248), . Jalife J (2016) Dynamics and Molecular Mechanisms of Ventricular Fibrillation in Structurally Normal Hearts, Cardiac Electrophysiology Clinics, 10.1016/j.ccep.2016.04.009, 8:3, (601-612), Online publication date: 1-Sep-2016. Shivkumar K, Ajijola O, Anand I, Armour J, Chen P, Esler M, De Ferrari G, Fishbein M, Goldberger J, Harper R, Joyner M, Khalsa S, Kumar R, Lane R, Mahajan A, Po S, Schwartz P, Somers V, Valderrabano M, Vaseghi M and Zipes D (2016) Clinical neurocardiology defining the value of neuroscience-based cardiovascular therapeutics, The Journal of Physiology, 10.1113/JP271870, 594:14, (3911-3954), Online publication date: 15-Jul-2016. Skibsbye L and Ravens U (2016) Mechanism of Proarrhythmic Effects of Potassium Channel Blockers, Cardiac Electrophysiology Clinics, 10.1016/j.ccep.2016.02.004, 8:2, (395-410), Online publication date: 1-Jun-2016. Laszlo R and Steinacker J (2015) Vorhofflimmern und körperliche AktivitätAtrial fibrillation and physical activity, Herz, 10.1007/s00059-015-4352-x, 41:2, (131-137), Online publication date: 1-Mar-2016. Tse G (2016) Mechanisms of cardiac arrhythmias, Journal of Arrhythmia, 10.1016/j.joa.2015.11.003, 32:2, (75-81), Online publication date: 1-Apr-2016. Boukens B, Walton R, Meijborg V and Coronel R (2016) Transmural electrophysiological heterogeneity, the T-wave and ventricular arrhythmias, Progress in Biophysics and Molecular Biology, 10.1016/j.pbiomolbio.2016.05.009, 122:3, (202-214), Online publication date: 1-Dec-2016. Anter E, Tschabrunn C, Buxton A and Josephson M (2016) High-Resolution Mapping of Postinfarction Reentrant Ventricular Tachycardia, Circulation, 10.1161/CIRCULATIONAHA.116.021955, 134:4, (314-327), Online publication date: 26-Jul-2016. Hua R, MacLeod S, Polina I, Moghtadaei M, Jansen H, Bogachev O, O’Blenes S, Sapp J, Legare J and Rose R (2015) Effects of Wild-Type and Mutant Forms of Atrial Natriuretic Peptide on Atrial Electrophysiology and Arrhythmogenesis, Circulation: Arrhythmia and Electrophysiology, 8:5, (1240-1254), Online publication date: 1-Oct-2015.Jabbari J, Olesen M, Yuan L, Nielsen J, Liang B, Macri V, Christophersen I, Nielsen N, Sajadieh A, Ellinor P, Grunnet M, Haunsø S, Holst A, Svendsen J and Jespersen T (2014) Common and Rare Variants in SCN10A Modulate the Risk of Atrial Fibrillation, Circulation: Cardiovascular Genetics, 8:1, (64-73), Online publication date: 1-Feb-2015. Boukens B, Gutbrod S and Efimov I (2015) Imaging of Ventricular Fibrillation and Defibrillation: The Virtual Electrode Hypothesis Membrane Potential Imaging in the Nervous System and Heart, 10.1007/978-3-319-17641-3_14, (343-365), . Subramanya S, Stephen B, Nair S, Schäfer K and Lammers W (2015) Effect of Ethanol Exposure on Slow Wave Activity and Smooth Muscle Contraction in the Rat Small Intestine, Digestive Diseases and Sciences, 10.1007/s10620-015-3813-7, 60:12, (3579-3589), Online publication date: 1-Dec-2015. KILLU A and MULPURU S (2015) Mapping and Ablation of Rotors: Exploring New Frontiers in Treatment of Ventricular Fibrillation, Journal of Cardiovascular Electrophysiology, 10.1111/jce.12760, 26:10, (1127-1129), Online publication date: 1-Oct-2015. ANGEL N, LI L, MACLEOD R, MARROUCHE N, RANJAN R and DOSDALL D (2015) Diverse Fibrosis Architecture and Premature Stimulation Facilitate Initiation of Reentrant Activity Following Chronic Atrial Fibrillation, Journal of Cardiovascular Electrophysiology, 10.1111/jce.12773, 26:12, (1352-1360), Online publication date: 1-Dec-2015. Algalarrondo V (2015) Physiopathologie de la fibrillation atriale à l’échelle cellulaire, Archives des Maladies du Coeur et des Vaisseaux - Pratique, 10.1016/S1261-694X(15)30019-5, 2015:235, (27-31), Online publication date: 1-Feb-2015. Lammers W (2014) Normal and abnormal electrical propagation in the small intestine, Acta Physiologica, 10.1111/apha.12371, 213:2, (349-359), Online publication date: 1-Feb-2015. Haugaard M, Pehrson S, Carstensen H, Flethøj M, Hesselkilde E, Praestegaard K, Diness J, Grunnet M, Jespersen T and Buhl R (2014) Antiarrhythmic and Electrophysiologic Effects of Flecainide on Acutely Induced Atrial Fibrillation in Healthy Horses, Journal of Veterinary Internal Medicine, 10.1111/jvim.12496, 29:1, (339-347), Online publication date: 1-Jan-2015. Lin C, Lin Y, Chung F and Chen S (2015) Focal atrial fibrillation presenting in the origin of atrial tachycardia, HeartRhythm Case Reports, 10.1016/j.hrcr.2014.10.003, 1:1, (18-21), Online publication date: 1-Jan-2015. Zaman J, Peters N and Narayan S (2015) Rotor mapping and ablation to treat atrial fibrillation, Current Opinion in Cardiology, 10.1097/HCO.0000000000000123, 30:1, (24-32), Online publication date: 1-Jan-2015. Anumonwo J and Pandit S (2015) Ionic mechanisms of arrhythmogenesis, Trends in Cardiovascular Medicine, 10.1016/j.tcm.2015.01.005, 25:6, (487-496), Online publication date: 1-Aug-2015. Aguilar M and Nattel S (2015) The Past, Present, and Potential Future of Sodium Channel Block as an Atrial Fibrillation Suppressing Strategy, Journal of Cardiovascular Pharmacology, 10.1097/FJC.0000000000000271, 66:5, (432-440), Online publication date: 1-Nov-2015. Clayton R and Nash M (2015) Analysis of Cardiac Fibrillation Using Phase Mapping, Cardiac Electrophysiology Clinics, 10.1016/j.ccep.2014.11.011, 7:1, (49-58), Online publication date: 1-Mar-2015. Kean A and Fischbach P (2015) P