CLIM-TIME Links Tumour Genetics to Spatial Immune Architecture

Weiwei Hu

Nature Reviews Cancer（2026）SCI 1区

Center for Excellence in Molecular Cell Science

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摘要

In this Tools of the Trade, Weiwei Hu describes the development and use of CLIM-TIME, a scalable in vivo platform that integrates CRISPR perturbation screens with spatially resolved transcriptomic and immune profiling to link tumour-intrinsic genetic alterations to distinct immune microenvironments.

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