Abstract Venous compliance is known to differ between uncomplicated and preeclamptic pregnancies and can be assessed using Doppler ultrasonography. The purpose of this report is to address some of the interfering conditions in order to illustrate some of the limitations of venous Doppler sonography. Five case reports of pregnant women with important morbidity were selected: (1) auto-immune vasculitis, (2) polycystic renal dysplasia, (3) hydronephrosis, (4) HELLP syndrome and (5) morbid obesity. All cases had a Doppler flow examination of renal interlobar veins according to a standardized protocol and venous impedance index of left and right kidney was calculated. Results were plotted on a normal reference curve. Renal venous Doppler sonography may be hampered by maternal comorbidities or disease-specific conditions due to which it is difficult or even impossible to perform or interpret the Doppler signal.