Prostate cancer is a prevalent and significant disease among men, leading to high mortality and morbidity worldwide. Various factors, including diet, lifestyle, and biological and environmental risks, are believed to contribute to prostate cancer progression. Consequently, the exploration of natural products as potential therapeutic agents for prostate cancer has gained attention. This study collected and analyzed clinical trial data from published research articles to investigate the chemopreventive properties, safety profile, and potential side effects of clinically investigated natural products in prostate cancer treatment. The consumption of phytochemical-rich foods has been proposed to minimize the chances of prostate cancer development. Notably, lycopene from tomatoes, green tea, broccoli, soy isoflavones, pomegranate fruit, omega-3 fatty acids from fish, and curcumin from turmeric have demonstrated significant chemopreventive activity in certain instances. Their effects were evaluated based on parameters such as prostate-specific antigen (PSA) levels, prostate cancer rates, progression, and hormonal markers. However, the outcomes of previous clinical trials investigating natural products in prostate cancer prevention remain inconclusive, possibly due to heterogeneity and limited sample sizes. To ascertain the true chemopreventive potential of these natural products, larger clinical trials involving diverse populations and further investigations are warranted. This review emphasizes the significance of natural products with emerging evidences in prostate cancer prevention, providing mechanistic insights and concise information from clinical trials.
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