Co-occurrence of Pfkelch13 and Pfmdr1 Variants in a Recurrent Plasmodium Falciparum Infection Following Standard Artemether-Lumefantrine Treatment

We report recurrent Plasmodium falciparum infection following standard artemether-lumefantrine treatment in a patient with metabolic comorbidities carrying mutant parasites presenting pfkelch13 and pfmdr1 variants, underscoring the need for genomic surveillance of antimalarial resistance and further investigation of host factors that may influence antimalarial drug exposure.