Comment On

N. Chartrel, R. Alvear-Perez, J. Leprince, X. Iturrioz,A. Reaux-Le Goazigo, V. Audinot, P. Chomarat,F. Coge,O. Nosjean, M. Rodriguez, J. P. Galizzi, J. A. Boutin, H. Vaudry, C. Llorens-Cortes

Science（2007）SCI 1区

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摘要

Zhang et al . (Research Articles, 11 November 2005, p. 996) reported that obestatin, a peptide derived from the ghrelin precursor, activated the orphan G protein–coupled receptor GPR39. However, we found that I 125 -obestatin does not bind GPR39 and observed no effects of obestatin on GPR39-transfected cells in various functional assays (cyclic adenosine monophosphate production, calcium mobilization, and GPR39 internalization). Our results indicate that obestatin is not the cognate ligand for GPR39.

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