Comparison of Normal Values of Igg Subclasses

The concentrations of subclasses of IgG in sera from children as reported by several groups were analyzed. A 4th degree polynomial regression curve was calculated for the upper and lower ranges of the subclasses at various ages. In addition percentile values were calculated. The calculated ranges were tested for their usefulness when looking for immunoglobulin subclass deficiencies. In relation to the calculated ranges the sera from 85 controls did not show decreased concentrations of IgG1 or IgG3. Eight % of the sera showed decreased IgG2 and no evaluation was possible for IgG4. We conclude that the calculated ranges of the IgG subclasses are useful for further research on IgG subclass deficiencies