We studied the role of CD38/АDP-ribosyl cyclase in development of inflammation in bronchial asthma, and relationship of its expression to the levels of cytokines in blood serum. We assessed expression of СD38 in peripheral blood lymphocytes in severe and mild bronchial asthma. We found the elevated expression of CD38 in peripheral blood lymphocytes in patients of both groups in an exacerbation in comparison with control group. Elevated expression of CD38, presumably, contributes to interactions of activated lymphocytes with endothelial cells due to CD38-CD31 interactions (the latter serves as a non-substrate ligand of CD38). As a result, endothelial cells are damaged, soluble form of CD31 (sPECAM-1) is released, and endothelial dysfunction is developed. These events lead to alterations in endothelium-dependent regulation of vessel wall elasticity and increasing of its rigidity.
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