Decline of Antibodies to Major Viral and Bacterial Respiratory Pathogens During the COVID-19 Pandemic

Surges in infections caused by respiratory pathogens have been documented in multiple settings after relaxation of pandemic restrictions. Antibodies to major antigens from respiratory syncytial virus and group A Streptococcus waned significantly in a longitudinal adult cohort throughout the pandemic. This waning may have contributed to the pathogen-surges that followed. Antibodies to respiratory syncytial virus and group A Streptococcus waned significantly in a longitudinal cohort throughout the pandemic. This waning may have contributed to the infection surges caused by these pathogens when restrictions were relaxed.