Does Deep Brain Stimulation Worsen Cognitive Decline in GBA-Parkinson Disease Patients? A Longitudinal Study of the Italian PARKNET Cohort

Background: GBA mutations are known to increase risk of Parkinson disease (PD) and to influence mainly its non-motor outcome. Deep brain stimulation (DBS) is a good therapeutic option for advanced PD, with major improvement of motor symptoms also in GBA-PD patients. However, a recent study suggested that DBS could accelerate cognitive decline in GBA carriers, raising concerns on its indication. We elucidated long-term impact of DBS on motor and non-motor features in GBA-PD.